TY - JOUR
T1 - Immunohistochemical localization of anterior pituitary hormones in S-100 protein-positive cells in the rat pituitary gland
AU - Kikuchi, Motoshi
AU - Yatabe, Megumi
AU - Tando, Yukiko
AU - Yashiro, Takashi
N1 - Funding Information:
Acknowledgement This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan to M.K. and T.Y. We thank David Kipler, ELS of Supernatant Communications, for revising the language of the manuscript.
PY - 2011/9
Y1 - 2011/9
N2 - In the anterior and intermediate lobes of the rat pituitary gland, non-hormone-producing cells that express S-100 protein coexist with various types of hormone-producing cells and are believed to function as phagocytes, supporting and paracrine-controlling cells of hormone-producing cells and stem cells, among other functions; however, their cytological characteristics are not yet fully understood. Using a transgenic rat that expresses green fluorescent protein under the promoter of the S100β protein gene, we immunohistochemically detected expression of the luteinizing hormone, thyroid-stimulating hormone, prolactin, growth hormone and proopiomelanocortin by S-100 protein-positive cells located between clusters of hormone-producing cells in the intermediate lobe. These findings lend support to the hypothesis that S-100 protein-positive cells are capable of differentiating into hormone-producing cells in the adult rat pituitary gland.
AB - In the anterior and intermediate lobes of the rat pituitary gland, non-hormone-producing cells that express S-100 protein coexist with various types of hormone-producing cells and are believed to function as phagocytes, supporting and paracrine-controlling cells of hormone-producing cells and stem cells, among other functions; however, their cytological characteristics are not yet fully understood. Using a transgenic rat that expresses green fluorescent protein under the promoter of the S100β protein gene, we immunohistochemically detected expression of the luteinizing hormone, thyroid-stimulating hormone, prolactin, growth hormone and proopiomelanocortin by S-100 protein-positive cells located between clusters of hormone-producing cells in the intermediate lobe. These findings lend support to the hypothesis that S-100 protein-positive cells are capable of differentiating into hormone-producing cells in the adult rat pituitary gland.
KW - Folliculo-stellate cell
KW - Intermediate lobe
KW - Pituitary
KW - Pituitary hormone
KW - S-100 protein
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U2 - 10.1007/s00441-011-1214-6
DO - 10.1007/s00441-011-1214-6
M3 - Article
C2 - 21830043
AN - SCOPUS:80052761320
VL - 345
SP - 425
EP - 429
JO - Zeitschrift für Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948)
JF - Zeitschrift für Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948)
SN - 0302-766X
IS - 3
ER -