Immunohistochemical localization of anterior pituitary hormones in S-100 protein-positive cells in the rat pituitary gland

Motoshi Kikuchi, Megumi Yatabe, Yukiko Tando, Takashi Yashiro

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

In the anterior and intermediate lobes of the rat pituitary gland, non-hormone-producing cells that express S-100 protein coexist with various types of hormone-producing cells and are believed to function as phagocytes, supporting and paracrine-controlling cells of hormone-producing cells and stem cells, among other functions; however, their cytological characteristics are not yet fully understood. Using a transgenic rat that expresses green fluorescent protein under the promoter of the S100β protein gene, we immunohistochemically detected expression of the luteinizing hormone, thyroid-stimulating hormone, prolactin, growth hormone and proopiomelanocortin by S-100 protein-positive cells located between clusters of hormone-producing cells in the intermediate lobe. These findings lend support to the hypothesis that S-100 protein-positive cells are capable of differentiating into hormone-producing cells in the adult rat pituitary gland.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalCell and Tissue Research
Volume345
Issue number3
DOIs
Publication statusPublished - 2011 Sep

Keywords

  • Folliculo-stellate cell
  • Intermediate lobe
  • Pituitary
  • Pituitary hormone
  • S-100 protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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