Immunohistochemical evaluation of MUC1 mucin expression in non-small cell lung cancers

Hiroshi Hashimoto, Hiroto Takahashi, Motoyasu Sagawa, Masami Sato, Chiaki Endo, Akira Sakurada, Hirokazu Aikawa, Nobuyuki Sato, Yasuki Saito, Shigefumi Fujimura

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the immunohistochemical expression of carcinoma- associated MUC1 in human lung cancer tissues using the monoclonal antibody MUSE11. We also investigated the expression of sialyl-Lewis x (sLe(x)) using monoclonal antibody FH-6. According to the histological type of lung cancer, MUSE11 positivity was observed in 90% of patients with adenocarcinoma (72/80), 51.6% of patients with squamous cell carcinoma (49/95), and 54.5% of patients with large cell carcinoma (12/22). A significant difference was detected in the expression of MUSE11 between adenocarcinoma and the two other histological types. Thus, MUSE11 appears to be a candidate for a tumor- associated marker in patients with lung adenocarcinoma. There was no relationship between the expression of MUSE11 and T factors, N factors, pathological stage, grade of differentiation, or prognosis. A significant relationship was detected between the expression of MUSE11 and that of FH-6. Earlier studies have revealed that part of sLe is associated with the MUC1 polypeptide. Our results suggested that the relationship also existed in human lung cancer specimens.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalJapanese Journal of Lung Cancer
Volume40
Issue number2
DOIs
Publication statusPublished - 2000 Apr

Keywords

  • FH-6
  • Immunohistochemistry
  • Lung cancer
  • MUC1
  • MUSE11

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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