TY - JOUR
T1 - Immunohistochemical evaluation of MUC1 mucin expression in non-small cell lung cancers
AU - Hashimoto, Hiroshi
AU - Takahashi, Hiroto
AU - Sagawa, Motoyasu
AU - Sato, Masami
AU - Endo, Chiaki
AU - Sakurada, Akira
AU - Aikawa, Hirokazu
AU - Sato, Nobuyuki
AU - Saito, Yasuki
AU - Fujimura, Shigefumi
PY - 2000/4
Y1 - 2000/4
N2 - We investigated the immunohistochemical expression of carcinoma- associated MUC1 in human lung cancer tissues using the monoclonal antibody MUSE11. We also investigated the expression of sialyl-Lewis x (sLe(x)) using monoclonal antibody FH-6. According to the histological type of lung cancer, MUSE11 positivity was observed in 90% of patients with adenocarcinoma (72/80), 51.6% of patients with squamous cell carcinoma (49/95), and 54.5% of patients with large cell carcinoma (12/22). A significant difference was detected in the expression of MUSE11 between adenocarcinoma and the two other histological types. Thus, MUSE11 appears to be a candidate for a tumor- associated marker in patients with lung adenocarcinoma. There was no relationship between the expression of MUSE11 and T factors, N factors, pathological stage, grade of differentiation, or prognosis. A significant relationship was detected between the expression of MUSE11 and that of FH-6. Earlier studies have revealed that part of sLe is associated with the MUC1 polypeptide. Our results suggested that the relationship also existed in human lung cancer specimens.
AB - We investigated the immunohistochemical expression of carcinoma- associated MUC1 in human lung cancer tissues using the monoclonal antibody MUSE11. We also investigated the expression of sialyl-Lewis x (sLe(x)) using monoclonal antibody FH-6. According to the histological type of lung cancer, MUSE11 positivity was observed in 90% of patients with adenocarcinoma (72/80), 51.6% of patients with squamous cell carcinoma (49/95), and 54.5% of patients with large cell carcinoma (12/22). A significant difference was detected in the expression of MUSE11 between adenocarcinoma and the two other histological types. Thus, MUSE11 appears to be a candidate for a tumor- associated marker in patients with lung adenocarcinoma. There was no relationship between the expression of MUSE11 and T factors, N factors, pathological stage, grade of differentiation, or prognosis. A significant relationship was detected between the expression of MUSE11 and that of FH-6. Earlier studies have revealed that part of sLe is associated with the MUC1 polypeptide. Our results suggested that the relationship also existed in human lung cancer specimens.
KW - FH-6
KW - Immunohistochemistry
KW - Lung cancer
KW - MUC1
KW - MUSE11
UR - http://www.scopus.com/inward/record.url?scp=0034029629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034029629&partnerID=8YFLogxK
U2 - 10.2482/haigan.40.85
DO - 10.2482/haigan.40.85
M3 - Article
AN - SCOPUS:0034029629
VL - 40
SP - 85
EP - 91
JO - Japanese Journal of Lung Cancer
JF - Japanese Journal of Lung Cancer
SN - 0386-9628
IS - 2
ER -