Immunohistochemical distribution of chicken ovalbumin upstream promoter transcription factor II in human tissues

Takashi Suzuki, Takuya Moriya, Andrew D. Darnel, Junji Takeyama, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is an orphan member of the steroid/thyroid hormone receptor superfamily. The present study examines the immunohistochemical distribution of COUP-TFII in human adult tissues. In the reproductive and endocrine systems, COUP-TFII immunoreactivity was detected in the stroma, vascular endothelium and smooth muscle, while it was less frequent in adrenal 4 binding protein (Ad4BP) positive steroidogenic cells. In lung, COUP-TFII immunoreactivity was detected in the vascular endothelium of alveolar septae. In kidney, the glomerular endothelium and Bowman's capsule were immunopositive for COUP- TFII. COUP-TFII immunoreactivity in the gastro-intestinal tract, liver and spleen were detected in mesenchymal cells, sinusoid endothelium and reticuloendothelium, respectively. Results from this study demonstrated the detection of COUP-TFII immunoreactivity in all human tissues examined, especially in mesenchymal cells. The widespread expression of COUP-TFII suggests that COUP-TFII may play an important role in the function and homeostasis of various human tissues and organs. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume164
Issue number1-2
DOIs
Publication statusPublished - 2000 Jun 20

Keywords

  • Adrenal 4 binding protein
  • Chicken ovalbumin upstream promoter factor
  • Human tissue
  • Immunohistochemistry

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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