Immunohistochemical Detection of Sheep Podoplanin Using an Antibovine Podoplanin Monoclonal Antibody PMab-44

Yukinari Kato, Shinji Yamada, Shunsuke Itai, Atsushi Kobayashi, Satoru Konnai, Mika K. Kaneko

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Podoplanin (PDPN) obtained from various animal species has been characterized using specific anti-PDPN monoclonal antibodies (mAbs), namely, PMab-1, PMab-2, PMab-32, PMab-38, PMab-44, and PMab-52 against mouse, rat, rabbit, dog, bovine, and cat PDPN, respectively. PDPN is expressed in type I alveolar cells in lungs, lymphatic endothelial cells, and kidney podocytes. In this study, we investigated possible cross-reactions between anti-PDPN mAbs and sheep PDPN. Type I alveolar cells from sheep lung were strongly detected by PMab-44 using immunohistochemical analyses. These results indicate that PMab-44 may be useful for the detection of sheep PDPN.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalMonoclonal antibodies in immunodiagnosis and immunotherapy
Volume37
Issue number6
DOIs
Publication statusPublished - 2018 Dec

Keywords

  • PMab-44
  • sheep PDPN
  • sheep podoplanin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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