Immunohistochemical detection of autotaxin (ATX)/lysophospholipase D (lysoPLD) in submucosal invasive colorectal cancer

Shinsuke Kazama, Joji Kitayama, Junken Aoki, Ken Mori, Hirokazu Nagawa

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Purpose: Autotaxin (ATX) is molecularly identical to lysophospholipase D (lysoPLD) and is a main enzyme producing lysophosphatidic acid (LPA), which mediates a broad range of cellular responses including stimulation of cell motility. Patients and Methods: Using immunohistochemical staining, we examined the expression of ATX/lysoPLD in 98 cases of early colorectal cancer with submucosal invasion. ATX/lysoPLD was highly expressed in infiltrating cells in tumor tissue in the submucosal layer, which were characterized as mast cells. Results: The number of ATX/lysoPLD-positive cells was significantly greater in tumors with a macroscopically depressed lesion than in tumors without depression. The density of ATX/lysoPLD-positive cells tended to have a positive correlation with microvessel vascular density (MVD), while it was not correlated with vessel invasion and nodal metastases as well as lymphovascular vessel density (LVD). Conclusion: Our results suggest that local production of LPA through ATX/lysoPLD may weakly correlate with formation of a depressive lesion and tumor angiogenesis in the early stage of colorectal cancer.

Original languageEnglish
Pages (from-to)204-211
Number of pages8
JournalJournal of Gastrointestinal Cancer
Volume42
Issue number4
DOIs
Publication statusPublished - 2011 Dec 1

Keywords

  • autotaxin
  • colon cancer
  • lysophospholipase D
  • submucosa

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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