Abstract
Purpose: Autotaxin (ATX) is molecularly identical to lysophospholipase D (lysoPLD) and is a main enzyme producing lysophosphatidic acid (LPA), which mediates a broad range of cellular responses including stimulation of cell motility. Patients and Methods: Using immunohistochemical staining, we examined the expression of ATX/lysoPLD in 98 cases of early colorectal cancer with submucosal invasion. ATX/lysoPLD was highly expressed in infiltrating cells in tumor tissue in the submucosal layer, which were characterized as mast cells. Results: The number of ATX/lysoPLD-positive cells was significantly greater in tumors with a macroscopically depressed lesion than in tumors without depression. The density of ATX/lysoPLD-positive cells tended to have a positive correlation with microvessel vascular density (MVD), while it was not correlated with vessel invasion and nodal metastases as well as lymphovascular vessel density (LVD). Conclusion: Our results suggest that local production of LPA through ATX/lysoPLD may weakly correlate with formation of a depressive lesion and tumor angiogenesis in the early stage of colorectal cancer.
Original language | English |
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Pages (from-to) | 204-211 |
Number of pages | 8 |
Journal | Journal of Gastrointestinal Cancer |
Volume | 42 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2011 Dec |
Keywords
- autotaxin
- colon cancer
- lysophospholipase D
- submucosa
ASJC Scopus subject areas
- Oncology
- Gastroenterology