Immunohistochemical demonstration of steroid C21 hydroxylase in normal and neoplastic human breasts

Hironobu Sasano; Nobuaki Sasano

doi:10.1002/1097-0142(19880915)62:6<1183::AID-CNCR2820620623>3.0.CO;2-W

Immunohistochemical demonstration of steroid C21 hydroxylase in normal and neoplastic human breasts

Hironobu Sasano, Nobuaki Sasano

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Steroid C21 hydroxylase was investigated immunohistochemically with the use of antibody against cytochrome P‐450 specific for steroid C21 hydroxylation (P‐450_C21) in normal and neoplastic human breast tissues. In the histologically normal breast, P‐450_C21 was exclusively present in secretory tubules and ducts. In mammary dysplasia and fibroadenoma, P‐450_C21 was intensively stained in epithelial cells. In gynecomastia, P‐450_C21 was faintly observed in epithelial cells in some cases. In intraductal and invasive ductal carcinoma, P‐450_C21 was observed in the cells with ductal formation. P‐450_C21 was not observed in medullary and mucinous carcinoma. In lobular carcinoma, only two cases were positive for P‐450_C21 of nine cases examined. P‐450_C21 is considered to be closely related to the ductal differentiation in neoplastic transformation of the breast.

Original language	English
Pages (from-to)	1183-1187
Number of pages	5
Journal	Cancer
Volume	62
Issue number	6
DOIs	https://doi.org/10.1002/1097-0142(19880915)62:6<1183::AID-CNCR2820620623>3.0.CO;2-W
Publication status	Published - 1988 Sep 15
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19880915)62:6<1183::AID-CNCR2820620623>3.0.CO;2-W

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title = "Immunohistochemical demonstration of steroid C21 hydroxylase in normal and neoplastic human breasts",

abstract = "Steroid C21 hydroxylase was investigated immunohistochemically with the use of antibody against cytochrome P‐450 specific for steroid C21 hydroxylation (P‐450C21) in normal and neoplastic human breast tissues. In the histologically normal breast, P‐450C21 was exclusively present in secretory tubules and ducts. In mammary dysplasia and fibroadenoma, P‐450C21 was intensively stained in epithelial cells. In gynecomastia, P‐450C21 was faintly observed in epithelial cells in some cases. In intraductal and invasive ductal carcinoma, P‐450C21 was observed in the cells with ductal formation. P‐450C21 was not observed in medullary and mucinous carcinoma. In lobular carcinoma, only two cases were positive for P‐450C21 of nine cases examined. P‐450C21 is considered to be closely related to the ductal differentiation in neoplastic transformation of the breast.",

author = "Hironobu Sasano and Nobuaki Sasano",

year = "1988",

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T1 - Immunohistochemical demonstration of steroid C21 hydroxylase in normal and neoplastic human breasts

AU - Sasano, Hironobu

AU - Sasano, Nobuaki

PY - 1988/9/15

Y1 - 1988/9/15

N2 - Steroid C21 hydroxylase was investigated immunohistochemically with the use of antibody against cytochrome P‐450 specific for steroid C21 hydroxylation (P‐450C21) in normal and neoplastic human breast tissues. In the histologically normal breast, P‐450C21 was exclusively present in secretory tubules and ducts. In mammary dysplasia and fibroadenoma, P‐450C21 was intensively stained in epithelial cells. In gynecomastia, P‐450C21 was faintly observed in epithelial cells in some cases. In intraductal and invasive ductal carcinoma, P‐450C21 was observed in the cells with ductal formation. P‐450C21 was not observed in medullary and mucinous carcinoma. In lobular carcinoma, only two cases were positive for P‐450C21 of nine cases examined. P‐450C21 is considered to be closely related to the ductal differentiation in neoplastic transformation of the breast.

AB - Steroid C21 hydroxylase was investigated immunohistochemically with the use of antibody against cytochrome P‐450 specific for steroid C21 hydroxylation (P‐450C21) in normal and neoplastic human breast tissues. In the histologically normal breast, P‐450C21 was exclusively present in secretory tubules and ducts. In mammary dysplasia and fibroadenoma, P‐450C21 was intensively stained in epithelial cells. In gynecomastia, P‐450C21 was faintly observed in epithelial cells in some cases. In intraductal and invasive ductal carcinoma, P‐450C21 was observed in the cells with ductal formation. P‐450C21 was not observed in medullary and mucinous carcinoma. In lobular carcinoma, only two cases were positive for P‐450C21 of nine cases examined. P‐450C21 is considered to be closely related to the ductal differentiation in neoplastic transformation of the breast.

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Immunohistochemical demonstration of steroid C21 hydroxylase in normal and neoplastic human breasts

Abstract

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UN SDGs

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