TY - JOUR
T1 - Immunohistochemical demonstration of steroid C21 hydroxylase in normal and neoplastic human breasts
AU - Sasano, Hironobu
AU - Sasano, Nobuaki
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1988/9/15
Y1 - 1988/9/15
N2 - Steroid C21 hydroxylase was investigated immunohistochemically with the use of antibody against cytochrome P‐450 specific for steroid C21 hydroxylation (P‐450C21) in normal and neoplastic human breast tissues. In the histologically normal breast, P‐450C21 was exclusively present in secretory tubules and ducts. In mammary dysplasia and fibroadenoma, P‐450C21 was intensively stained in epithelial cells. In gynecomastia, P‐450C21 was faintly observed in epithelial cells in some cases. In intraductal and invasive ductal carcinoma, P‐450C21 was observed in the cells with ductal formation. P‐450C21 was not observed in medullary and mucinous carcinoma. In lobular carcinoma, only two cases were positive for P‐450C21 of nine cases examined. P‐450C21 is considered to be closely related to the ductal differentiation in neoplastic transformation of the breast.
AB - Steroid C21 hydroxylase was investigated immunohistochemically with the use of antibody against cytochrome P‐450 specific for steroid C21 hydroxylation (P‐450C21) in normal and neoplastic human breast tissues. In the histologically normal breast, P‐450C21 was exclusively present in secretory tubules and ducts. In mammary dysplasia and fibroadenoma, P‐450C21 was intensively stained in epithelial cells. In gynecomastia, P‐450C21 was faintly observed in epithelial cells in some cases. In intraductal and invasive ductal carcinoma, P‐450C21 was observed in the cells with ductal formation. P‐450C21 was not observed in medullary and mucinous carcinoma. In lobular carcinoma, only two cases were positive for P‐450C21 of nine cases examined. P‐450C21 is considered to be closely related to the ductal differentiation in neoplastic transformation of the breast.
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U2 - 10.1002/1097-0142(19880915)62:6<1183::AID-CNCR2820620623>3.0.CO;2-W
DO - 10.1002/1097-0142(19880915)62:6<1183::AID-CNCR2820620623>3.0.CO;2-W
M3 - Article
C2 - 2842033
AN - SCOPUS:0023719842
VL - 62
SP - 1183
EP - 1187
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 6
ER -