Immunohistochemical demonstration of steroid C21 hydroxylase in normal and neoplastic human breasts

Hironobu Sasano, Nobuaki Sasano

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3 Citations (Scopus)


Steroid C21 hydroxylase was investigated immunohistochemically with the use of antibody against cytochrome P‐450 specific for steroid C21 hydroxylation (P‐450C21) in normal and neoplastic human breast tissues. In the histologically normal breast, P‐450C21 was exclusively present in secretory tubules and ducts. In mammary dysplasia and fibroadenoma, P‐450C21 was intensively stained in epithelial cells. In gynecomastia, P‐450C21 was faintly observed in epithelial cells in some cases. In intraductal and invasive ductal carcinoma, P‐450C21 was observed in the cells with ductal formation. P‐450C21 was not observed in medullary and mucinous carcinoma. In lobular carcinoma, only two cases were positive for P‐450C21 of nine cases examined. P‐450C21 is considered to be closely related to the ductal differentiation in neoplastic transformation of the breast.

Original languageEnglish
Pages (from-to)1183-1187
Number of pages5
Issue number6
Publication statusPublished - 1988 Sep 15
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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