Immunohistochemical demonstration of neuropeptides in the articular disk of the human temporomandibular joint

Yasuko Haeuchi, Ken Matsumoto, Hiroyuki Ichikawa, Sadaaki Maeda

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The distribution of calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) was examined in the human temporomandibular articular disk using an indirect immunofluorescent method. All examined neuropeptides were observed in nerve fibers in the disk. These fibers were mostly located in the loose fibrous tissue of the posterior part (posterior attachment) and in the lateral region of the anterior part (anterolateral loose fibrous tissue) of the disk. The posterior attachment and anterolateral loose fibrous tissue occasionally contained isolated nerve fibers which usually showed immunoreactivity (IR) for CGRP or SP. In this tissue, perivascular fibers contained VIP or NPY, whereas isolated fibers and free nerve endings showed the IR for CGRP or SP. These neuropeptides may be involved in the regulation of blood flow and/or pain sensation in the human articular disk of the temporomandibular joint.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalCells Tissues Organs
Issue number4
Publication statusPublished - 1999 Aug 9
Externally publishedYes


  • Articular disk
  • Calcitonin gene related peptide
  • Neuropeptide Y
  • Substance P
  • Temporomandibular joint
  • Vasoactive intestinal polypeptide

ASJC Scopus subject areas

  • Anatomy
  • Histology


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