Immunohistochemical demonstration of hormone production in sclerosing stromal tumor

Mitsuko Furuya, Hiroshi Ishikura, Hironobu Sasano, Yoshihito Onaka, Kazuaki Inoue, Takashi Yoshiki, Seiichiro Fujimoto

Research output: Contribution to journalArticlepeer-review

Abstract

Sclerosing stromal tumor of the ovary (SST) is a rare, benign neoplasm in young women. Three cases of SST are studied for immunohistochemical detection of hormone and hormone synthetic enzymes. The SST Case 1 was a 61 years old, Case 2, 19 years old and Case 3, 27 years old. All three women were Japanese. Immunohistochemical studies of Cases 1 and 2 showed that tumor cells were positive for P-450 side chain cleavage, 3β-hydroxysteroid dehydrogenase. P-450 17α-hydroxylase and lyase. In Case 1, tumor cells were negative for P-450 aromatase, but they were positive in Case 2. These findings suggested the production of E2 precursors by tumor cells. Immunostain for E revealed some reactivity in tumor cells in Cases 1 and 3, but not in Case 2. The collective evidence indicates that some SST cells produce sex steroid hormone.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalActa Obstetrica et Gynaecologica Japonica
Volume49
Issue number2
Publication statusPublished - 1997 Feb

Keywords

  • Hormone production
  • Immunohistochemistry
  • Ovary
  • Sclerosing stromal tumor
  • Sex steroid biosynthesis enzymes (SSBEs)

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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