Immunohistochemical Biomarkers of Adrenal Cortical Neoplasms

Ozgur Mete, Sylvia L. Asa, Thomas J. Giordano, Mauro Papotti, Hironobu Sasano, Marco Volante

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)


Careful morphological evaluation forms the basis of the workup of an adrenal cortical neoplasm. However, the adoption of immunohistochemical biomarkers has added tremendous value to enhance diagnostic accuracy. The authors provide a brief review of immunohistochemical biomarkers that have been used in the confirmation of adrenal cortical origin and in the detection of the source of functional adrenal cortical proliferations, as well as diagnostic, predictive, and prognostic biomarkers of adrenal cortical carcinoma. In addition, a brief section on potential novel theranostic biomarkers in the prediction of treatment response to mitotane and other relevant chemotherapeutic agents is also provided. In the era of precision and personalized medical practice, adoption of combined morphology and immunohistochemistry provides a new approach to the diagnostic workup of adrenal cortical neoplasms, reflecting the evolution of clinical responsibility of pathologists.

Original languageEnglish
Pages (from-to)137-149
Number of pages13
JournalEndocrine Pathology
Issue number2
Publication statusPublished - 2018 Jun 1


  • Adrenal cortical carcinoma
  • Beta-catenin
  • CYP11B1
  • CYP11B2
  • IGF-2
  • Immunohistochemistry
  • Ki67
  • Mitotane
  • SF-1
  • p53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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