Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237

Shinji Yamada; Shunsuke Itai; Takuro Nakamura; Junko Takei; Masato Sano; Satoru Konnai; Atsushi Kobayashi; Shotaro Nakagun; Yoshiyasu Kobayashi; Mika K. Kaneko; Yukinari Kato

doi:10.1089/mab.2019.0014

Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237

Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Junko Takei, Masato Sano, Satoru Konnai, Atsushi Kobayashi, Shotaro Nakagun, Yoshiyasu Kobayashi, Mika K. Kaneko, Yukinari Kato

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Podoplanin (PDPN)/T1 alpha is known as a specific marker of lymphatic endothelial cells and type I alveolar cells. Sensitive and specific monoclonal antibodies (mAbs) for PDPN are needed for immunohistochemical analyses. Recently, we developed an anticetacean PDPN mAb, PMab-237. Herein, immunohistochemical analyses showed that PMab-237 strongly detected pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells of the harbor porpoise. These findings suggest that PMab-237 may be useful for immunohistochemical analyses for cetacean tissues.

Original language	English
Pages (from-to)	104-107
Number of pages	4
Journal	Monoclonal antibodies in immunodiagnosis and immunotherapy
Volume	38
Issue number	3
DOIs	https://doi.org/10.1089/mab.2019.0014
Publication status	Published - 2019 Jun

Keywords

PDPN
PMab-237
cetacean podoplanin
lymphatic endothelial cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1089/mab.2019.0014

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Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237. / Yamada, Shinji; Itai, Shunsuke; Nakamura, Takuro; Takei, Junko; Sano, Masato; Konnai, Satoru; Kobayashi, Atsushi; Nakagun, Shotaro; Kobayashi, Yoshiyasu; Kaneko, Mika K.; Kato, Yukinari.

In: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 38, No. 3, 06.2019, p. 104-107.

Research output: Contribution to journal › Article › peer-review

Yamada, Shinji ; Itai, Shunsuke ; Nakamura, Takuro ; Takei, Junko ; Sano, Masato ; Konnai, Satoru ; Kobayashi, Atsushi ; Nakagun, Shotaro ; Kobayashi, Yoshiyasu ; Kaneko, Mika K. ; Kato, Yukinari. / Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237. In: Monoclonal antibodies in immunodiagnosis and immunotherapy. 2019 ; Vol. 38, No. 3. pp. 104-107.

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abstract = "Podoplanin (PDPN)/T1 alpha is known as a specific marker of lymphatic endothelial cells and type I alveolar cells. Sensitive and specific monoclonal antibodies (mAbs) for PDPN are needed for immunohistochemical analyses. Recently, we developed an anticetacean PDPN mAb, PMab-237. Herein, immunohistochemical analyses showed that PMab-237 strongly detected pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells of the harbor porpoise. These findings suggest that PMab-237 may be useful for immunohistochemical analyses for cetacean tissues.",

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