Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237

Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Junko Takei, Masato Sano, Satoru Konnai, Atsushi Kobayashi, Shotaro Nakagun, Yoshiyasu Kobayashi, Mika K. Kaneko, Yukinari Kato

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Podoplanin (PDPN)/T1 alpha is known as a specific marker of lymphatic endothelial cells and type I alveolar cells. Sensitive and specific monoclonal antibodies (mAbs) for PDPN are needed for immunohistochemical analyses. Recently, we developed an anticetacean PDPN mAb, PMab-237. Herein, immunohistochemical analyses showed that PMab-237 strongly detected pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells of the harbor porpoise. These findings suggest that PMab-237 may be useful for immunohistochemical analyses for cetacean tissues.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalMonoclonal antibodies in immunodiagnosis and immunotherapy
Volume38
Issue number3
DOIs
Publication statusPublished - 2019 Jun

Keywords

  • PDPN
  • PMab-237
  • cetacean podoplanin
  • lymphatic endothelial cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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