Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237

Shinji Yamada; Shunsuke Itai; Takuro Nakamura; Junko Takei; Masato Sano; Satoru Konnai; Atsushi Kobayashi; Shotaro Nakagun; Yoshiyasu Kobayashi; Mika K. Kaneko; Yukinari Kato

doi:10.1089/mab.2019.0014

Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237

Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Junko Takei, Masato Sano, Satoru Konnai, Atsushi Kobayashi, Shotaro Nakagun, Yoshiyasu Kobayashi, Mika K. Kaneko, Yukinari Kato

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Podoplanin (PDPN)/T1 alpha is known as a specific marker of lymphatic endothelial cells and type I alveolar cells. Sensitive and specific monoclonal antibodies (mAbs) for PDPN are needed for immunohistochemical analyses. Recently, we developed an anticetacean PDPN mAb, PMab-237. Herein, immunohistochemical analyses showed that PMab-237 strongly detected pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells of the harbor porpoise. These findings suggest that PMab-237 may be useful for immunohistochemical analyses for cetacean tissues.

Original language	English
Pages (from-to)	104-107
Number of pages	4
Journal	Monoclonal antibodies in immunodiagnosis and immunotherapy
Volume	38
Issue number	3
DOIs	https://doi.org/10.1089/mab.2019.0014
Publication status	Published - 2019 Jun

Keywords

PDPN
PMab-237
cetacean podoplanin
lymphatic endothelial cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1089/mab.2019.0014

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title = "Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237",

abstract = "Podoplanin (PDPN)/T1 alpha is known as a specific marker of lymphatic endothelial cells and type I alveolar cells. Sensitive and specific monoclonal antibodies (mAbs) for PDPN are needed for immunohistochemical analyses. Recently, we developed an anticetacean PDPN mAb, PMab-237. Herein, immunohistochemical analyses showed that PMab-237 strongly detected pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells of the harbor porpoise. These findings suggest that PMab-237 may be useful for immunohistochemical analyses for cetacean tissues.",

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author = "Shinji Yamada and Shunsuke Itai and Takuro Nakamura and Junko Takei and Masato Sano and Satoru Konnai and Atsushi Kobayashi and Shotaro Nakagun and Yoshiyasu Kobayashi and Kaneko, {Mika K.} and Yukinari Kato",

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year = "2019",

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doi = "10.1089/mab.2019.0014",

language = "English",

volume = "38",

pages = "104--107",

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T1 - Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237

AU - Yamada, Shinji

AU - Itai, Shunsuke

AU - Nakamura, Takuro

AU - Takei, Junko

AU - Sano, Masato

AU - Konnai, Satoru

AU - Kobayashi, Atsushi

AU - Nakagun, Shotaro

AU - Kobayashi, Yoshiyasu

AU - Kaneko, Mika K.

AU - Kato, Yukinari

PY - 2019/6

Y1 - 2019/6

N2 - Podoplanin (PDPN)/T1 alpha is known as a specific marker of lymphatic endothelial cells and type I alveolar cells. Sensitive and specific monoclonal antibodies (mAbs) for PDPN are needed for immunohistochemical analyses. Recently, we developed an anticetacean PDPN mAb, PMab-237. Herein, immunohistochemical analyses showed that PMab-237 strongly detected pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells of the harbor porpoise. These findings suggest that PMab-237 may be useful for immunohistochemical analyses for cetacean tissues.

AB - Podoplanin (PDPN)/T1 alpha is known as a specific marker of lymphatic endothelial cells and type I alveolar cells. Sensitive and specific monoclonal antibodies (mAbs) for PDPN are needed for immunohistochemical analyses. Recently, we developed an anticetacean PDPN mAb, PMab-237. Herein, immunohistochemical analyses showed that PMab-237 strongly detected pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells of the harbor porpoise. These findings suggest that PMab-237 may be useful for immunohistochemical analyses for cetacean tissues.

KW - PDPN

KW - PMab-237

KW - cetacean podoplanin

KW - lymphatic endothelial cells

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DO - 10.1089/mab.2019.0014

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JO - Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

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Immunohistochemical Analysis of the Harbor Porpoise Using Antipodoplanin Antibody PMab-237

Abstract

Keywords

ASJC Scopus subject areas

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