Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour

Fumiaki Matsubara, Takuyuki Katabami, Shiko Asai, Yasushi Ariizumi, Ichiro Maeda, Masayuki Takagi, May Mc Namara Keely, Katsuhiko Ono, Takashi Maekawa, Yasuhiro Nakamura, Yasushi Tanaka, Hironobu Sasano

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1 Citation (Scopus)

Abstract

Objective: To investigate the immunohistochemical localization of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) in archival specimens of sporadic schwannoma. Method: This study retrospectively analysed the immunolocalization of IGF-1 and IGF-1R in schwannoma specimens collected from all patients with sporadic schwannoma that were treated by two institutions in Japan. The study also evaluated the association between the extent of the IGF-1 and IGF-1R immunoreactivity and several clinicopathological characteristics (age, sex and maximum tumour dimension). Results: The study examined a total of 29 sporadic schwannoma specimens. IGF-1 and IGF-1R immunoreactivity was detected in the majority of the specimens regardless of their anatomical location. IGF-1 and IGF-1R were not co-localized. There was no association between the extent of the IGF-1 and IGF-1R immunoreactivity and the clinicopathological characteristics of the patients. Conclusions: As IGF-1 and IGF-1R immunoreactivity was detected in the majority of sporadic schwannoma specimens regardless of their anatomical location, these findings suggest that an IGF-1/IGF-1R loop could play a role in the tumorigenesis and progression of schwannomas via an autocrine–paracrine mechanism.

Original languageEnglish
Pages (from-to)662-672
Number of pages11
JournalJournal of International Medical Research
Volume44
Issue number3
DOIs
Publication statusPublished - 2016

Keywords

  • Schwannoma
  • autocrine–paracrine loop
  • immunostaining
  • insulin-like growth factor 1
  • insulin-like growth factor 1 receptor
  • peripheral nerve sheath tumour

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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    Matsubara, F., Katabami, T., Asai, S., Ariizumi, Y., Maeda, I., Takagi, M., Keely, M. M. N., Ono, K., Maekawa, T., Nakamura, Y., Tanaka, Y., & Sasano, H. (2016). Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour. Journal of International Medical Research, 44(3), 662-672. https://doi.org/10.1177/0300060516637768