Immunoglobulin G antibody avidity assay for serodiagnosis of hepatitis C virus infection

Atsushi Kanno, Yukumasa Kazuyama

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


It has been reported that the avidity of specific IgG antibody is lower in primary viral infection than in chronic viral infection. However, few studies have been reported on the IgG avidity in hepatitis C virus (HCV) infection. In the present study, 36 patients with antibody to HCV (anti-HCV) were examined for IgG avidity by an enzyme immunoassay with or without urea elution. The avidity index was significantly low in patients with primary HCV infection (7.7 ± 6.8%, mean ± SD), compared with patients with chronic HCV infection (77.0 ± 21.8%) and individuals with past HCV infection (44.5 ± 12.6%). Temporal changes of IgG avidity were examined in six patients with primary HCV infection. The avidity index was low in the acute phase of the infection and then increased with time. These results suggest that the avidity assay for IgG anti-HCV is a useful method for distinguishing primary HCV infection from chronic or past HCV infection.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalJournal of Medical Virology
Issue number2
Publication statusPublished - 2002 Oct
Externally publishedYes


  • Anti-HCV
  • Avidity
  • IgG

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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