TY - JOUR
T1 - Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A
AU - Kotani, Shozo
AU - Takada, Haruhiko
AU - Tsujimoto, Masachika
AU - Ogawa, Tomohiko
AU - Harada, Kazuhiro
AU - Mori, Yoshihide
AU - Kawasaki, Akinori
AU - Tanaka, Atsushi
AU - Nagao, Shigeki
AU - Tanaka, Shigenori
AU - Shiba, Tetsuo
AU - Kusumoto, Shoichi
AU - Imoto, Masahiro
AU - Yoshimura, Hiroyuki
AU - Yamamoto, Michiharu
AU - Shimamoto, Tetsuo
PY - 1984
Y1 - 1984
N2 - Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of β(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosamine-treated mice was almost comparable to that of natural lipid A. The pyrogenicity and Shwartzmann induction activity of the synthetic analogs, however, were much less than those of natural lipid A.
AB - Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of β(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosamine-treated mice was almost comparable to that of natural lipid A. The pyrogenicity and Shwartzmann induction activity of the synthetic analogs, however, were much less than those of natural lipid A.
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U2 - 10.1128/iai.45.1.293-296.1984
DO - 10.1128/iai.45.1.293-296.1984
M3 - Article
C2 - 6735470
AN - SCOPUS:0021166151
VL - 45
SP - 293
EP - 296
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 1
ER -
