Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A

Shozo Kotani, Haruhiko Takada, Masachika Tsujimoto, Tomohiko Ogawa, Kazuhiro Harada, Yoshihide Mori, Akinori Kawasaki, Atsushi Tanaka, Shigeki Nagao, Shigenori Tanaka, Tetsuo Shiba, Shoichi Kusumoto, Masahiro Imoto, Hiroyuki Yoshimura, Michiharu Yamamoto, Tetsuo Shimamoto

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of β(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosamine-treated mice was almost comparable to that of natural lipid A. The pyrogenicity and Shwartzmann induction activity of the synthetic analogs, however, were much less than those of natural lipid A.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalInfection and immunity
Volume45
Issue number1
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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