Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L- alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes

S. Kotani; F. Kinoshita; I. Morisaki; T. Shimono; T. Okunaga; H. Takada; M. Tsujimoto; Y. Watanabe; K. Kato; T. Shiba; S. Kusumoto; S. Okada

Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L- alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes

S. Kotani, F. Kinoshita, I. Morisaki, T. Shimono, T. Okunaga, H. Takada, M. Tsujimoto, Y. Watanabe, K. Kato, T. Shiba, S. Kusumoto, S. Okada

DEN - Dental Sciences

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Addition of a lauroyl, stearoyl or docosanoyl group to the primary hydroxy group at the C-6 position of N-acetylmuramyl-L-alanyl-D-isoglutamine gave lipophilic derivatives that had definite adjuvancies in induction of delayed-type hypersensitivity and enhancement of antibody production against a test protein antigen, ovalbumin, when administered to guinea pigs as liposomes, that is, without mineral oil. When administered as mineral oil-in-water emulsion, including Ribi-type emulsions, rather than as water-in-mineral oil emulsions, N-acetylmuramyl-L-alanyl-D-isoglutamine and its 6-O-acyl derivatives showed only weak immunoadjuvancies.

Original language	English
Pages (from-to)	95-103
Number of pages	9
Journal	Biken Journal, Journal of the Research Institute for Microbial Diseases
Volume	20
Issue number	3-4
Publication status	Published - 1977

ASJC Scopus subject areas

Immunology and Microbiology(all)
Medicine(all)
Infectious Diseases
Microbiology (medical)

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Kotani, S., Kinoshita, F., Morisaki, I., Shimono, T., Okunaga, T., Takada, H., Tsujimoto, M., Watanabe, Y., Kato, K., Shiba, T., Kusumoto, S., & Okada, S. (1977). Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L- alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes. Biken Journal, Journal of the Research Institute for Microbial Diseases, 20(3-4), 95-103.

Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L- alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes. / Kotani, S.; Kinoshita, F.; Morisaki, I.; Shimono, T.; Okunaga, T.; Takada, H.; Tsujimoto, M.; Watanabe, Y.; Kato, K.; Shiba, T.; Kusumoto, S.; Okada, S.

In: Biken Journal, Journal of the Research Institute for Microbial Diseases, Vol. 20, No. 3-4, 1977, p. 95-103.

Research output: Contribution to journal › Article › peer-review

Kotani, S, Kinoshita, F, Morisaki, I, Shimono, T, Okunaga, T, Takada, H, Tsujimoto, M, Watanabe, Y, Kato, K, Shiba, T, Kusumoto, S & Okada, S 1977, 'Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L- alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes', Biken Journal, Journal of the Research Institute for Microbial Diseases, vol. 20, no. 3-4, pp. 95-103.

Kotani, S. ; Kinoshita, F. ; Morisaki, I. ; Shimono, T. ; Okunaga, T. ; Takada, H. ; Tsujimoto, M. ; Watanabe, Y. ; Kato, K. ; Shiba, T. ; Kusumoto, S. ; Okada, S. / Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L- alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes. In: Biken Journal, Journal of the Research Institute for Microbial Diseases. 1977 ; Vol. 20, No. 3-4. pp. 95-103.

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abstract = "Addition of a lauroyl, stearoyl or docosanoyl group to the primary hydroxy group at the C-6 position of N-acetylmuramyl-L-alanyl-D-isoglutamine gave lipophilic derivatives that had definite adjuvancies in induction of delayed-type hypersensitivity and enhancement of antibody production against a test protein antigen, ovalbumin, when administered to guinea pigs as liposomes, that is, without mineral oil. When administered as mineral oil-in-water emulsion, including Ribi-type emulsions, rather than as water-in-mineral oil emulsions, N-acetylmuramyl-L-alanyl-D-isoglutamine and its 6-O-acyl derivatives showed only weak immunoadjuvancies.",

author = "S. Kotani and F. Kinoshita and I. Morisaki and T. Shimono and T. Okunaga and H. Takada and M. Tsujimoto and Y. Watanabe and K. Kato and T. Shiba and S. Kusumoto and S. Okada",

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AU - Kotani, S.

AU - Kinoshita, F.

AU - Morisaki, I.

AU - Shimono, T.

AU - Okunaga, T.

AU - Takada, H.

AU - Tsujimoto, M.

AU - Watanabe, Y.

AU - Kato, K.

AU - Shiba, T.

AU - Kusumoto, S.

AU - Okada, S.

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AB - Addition of a lauroyl, stearoyl or docosanoyl group to the primary hydroxy group at the C-6 position of N-acetylmuramyl-L-alanyl-D-isoglutamine gave lipophilic derivatives that had definite adjuvancies in induction of delayed-type hypersensitivity and enhancement of antibody production against a test protein antigen, ovalbumin, when administered to guinea pigs as liposomes, that is, without mineral oil. When administered as mineral oil-in-water emulsion, including Ribi-type emulsions, rather than as water-in-mineral oil emulsions, N-acetylmuramyl-L-alanyl-D-isoglutamine and its 6-O-acyl derivatives showed only weak immunoadjuvancies.

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