Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L- alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes

S. Kotani, F. Kinoshita, I. Morisaki, T. Shimono, T. Okunaga, H. Takada, M. Tsujimoto, Y. Watanabe, K. Kato, T. Shiba, S. Kusumoto, S. Okada

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36 Citations (Scopus)

Abstract

Addition of a lauroyl, stearoyl or docosanoyl group to the primary hydroxy group at the C-6 position of N-acetylmuramyl-L-alanyl-D-isoglutamine gave lipophilic derivatives that had definite adjuvancies in induction of delayed-type hypersensitivity and enhancement of antibody production against a test protein antigen, ovalbumin, when administered to guinea pigs as liposomes, that is, without mineral oil. When administered as mineral oil-in-water emulsion, including Ribi-type emulsions, rather than as water-in-mineral oil emulsions, N-acetylmuramyl-L-alanyl-D-isoglutamine and its 6-O-acyl derivatives showed only weak immunoadjuvancies.

Original languageEnglish
Pages (from-to)95-103
Number of pages9
JournalBiken Journal, Journal of the Research Institute for Microbial Diseases
Volume20
Issue number3-4
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Infectious Diseases
  • Microbiology (medical)

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