TY - JOUR
T1 - Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L- alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes
AU - Kotani, S.
AU - Kinoshita, F.
AU - Morisaki, I.
AU - Shimono, T.
AU - Okunaga, T.
AU - Takada, H.
AU - Tsujimoto, M.
AU - Watanabe, Y.
AU - Kato, K.
AU - Shiba, T.
AU - Kusumoto, S.
AU - Okada, S.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 1977
Y1 - 1977
N2 - Addition of a lauroyl, stearoyl or docosanoyl group to the primary hydroxy group at the C-6 position of N-acetylmuramyl-L-alanyl-D-isoglutamine gave lipophilic derivatives that had definite adjuvancies in induction of delayed-type hypersensitivity and enhancement of antibody production against a test protein antigen, ovalbumin, when administered to guinea pigs as liposomes, that is, without mineral oil. When administered as mineral oil-in-water emulsion, including Ribi-type emulsions, rather than as water-in-mineral oil emulsions, N-acetylmuramyl-L-alanyl-D-isoglutamine and its 6-O-acyl derivatives showed only weak immunoadjuvancies.
AB - Addition of a lauroyl, stearoyl or docosanoyl group to the primary hydroxy group at the C-6 position of N-acetylmuramyl-L-alanyl-D-isoglutamine gave lipophilic derivatives that had definite adjuvancies in induction of delayed-type hypersensitivity and enhancement of antibody production against a test protein antigen, ovalbumin, when administered to guinea pigs as liposomes, that is, without mineral oil. When administered as mineral oil-in-water emulsion, including Ribi-type emulsions, rather than as water-in-mineral oil emulsions, N-acetylmuramyl-L-alanyl-D-isoglutamine and its 6-O-acyl derivatives showed only weak immunoadjuvancies.
UR - http://www.scopus.com/inward/record.url?scp=0017573866&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017573866&partnerID=8YFLogxK
M3 - Article
C2 - 614856
AN - SCOPUS:0017573866
VL - 20
SP - 95
EP - 103
JO - Biken Journal, Journal of the Research Institute for Microbial Diseases
JF - Biken Journal, Journal of the Research Institute for Microbial Diseases
SN - 0006-2324
IS - 3-4
ER -