Addition of a lauroyl, stearoyl or docosanoyl group to the primary hydroxy group at the C-6 position of N-acetylmuramyl-L-alanyl-D-isoglutamine gave lipophilic derivatives that had definite adjuvancies in induction of delayed-type hypersensitivity and enhancement of antibody production against a test protein antigen, ovalbumin, when administered to guinea pigs as liposomes, that is, without mineral oil. When administered as mineral oil-in-water emulsion, including Ribi-type emulsions, rather than as water-in-mineral oil emulsions, N-acetylmuramyl-L-alanyl-D-isoglutamine and its 6-O-acyl derivatives showed only weak immunoadjuvancies.
|Number of pages||9|
|Journal||Biken Journal, Journal of the Research Institute for Microbial Diseases|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Infectious Diseases
- Microbiology (medical)