Abstract
Among various strains of mice immunized orally with Porphyromonas gingivalis fimbriae and adjuvant GM-53 in liposomes, BALB/c and DBA/2 mice (H-2(d)) were found to be high responders to the fimbriae, CBA/J and C3H mice (H-2(k)) were intermediate, while C57BL/6 mice were low responders in terms of serum IgG and salivary IgA responses. Furthermore, humoral immune responses were examined using congeneic mice of B10 background showing different H-2 haplotypes, and it was revealed that B10.D2 mice (H-2(d)), followed by B10.BR (H-2(k)), responded well to antigenic stimulation of the fimbriae, while C57BL/10 mice (B10, H-2b) were low responders to the fimbriae. Hybrids between BALB/c and C57BL/6 mice were found to reflect a phenotype of low responders. Thus, the humoral immune responses to P. gingivalis in mice are restricted by H-2 haplotype.
Original language | English |
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Pages (from-to) | 362-364 |
Number of pages | 3 |
Journal | Immunology |
Volume | 74 |
Issue number | 2 |
Publication status | Published - 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology