Imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy

Takuya Asai, Hanqin Liu, Yasuyuki Ozeki, Shinichi Sato, Tomohiro Hayashi, Hiroyuki Nakamura

Research output: Contribution to journalArticle

Abstract

Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy to treat malignant tumors using a nuclear reaction of boron isotopes in tumor-localizing drug molecules. To evaluate the efficacy of boron drugs for BNCT, it is crucial to measure the distribution of boron drugs in cells. Here, we present the direct imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy. We demonstrate quantitative analysis of spatial distributions of disodium mercaptoundecahydrododecaborate (BSH)-cholesterol in HeLa cells.

Original languageEnglish
Article number112004
JournalApplied Physics Express
Volume12
Issue number11
DOIs
Publication statusPublished - 2019 Nov 1
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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