Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: Comparison with [11C]PIB

Hiroshi Ito, Hitoshi Shinotoh, Hitoshi Shimada, Michie Miyoshi, Kazuhiko Yanai, Nobuyuki Okamura, Harumasa Takano, Hidehiko Takahashi, Ryosuke Arakawa, Fumitoshi Kodaka, Maiko Ono, Yoko Eguchi, Makoto Higuchi, Toshimitsu Fukumura, Tetsuya Suhara

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Purpose: The characteristic neuropathological changes in Alzheimer's disease (AD) are deposition of amyloid senile plaques and neurofibrillary tangles. The 18F-labeled amyloid tracer, [18F]2-[(2-{(E)- 2-[2-(dimethylamino)-1,3-thiazol-5-yl]vinyl}-1,3-benzoxazol-6-yl)oxy] -3-fluoropropan-1-ol (FACT), one of the benzoxazole derivatives, was recently developed. In the present study, deposition of amyloid senile plaques was measured by positron emission tomography (PET) with both [11C] Pittsburgh compound B (PIB) and [18F]FACT in the same subjects, and the regional uptakes of both radiotracers were directly compared. Methods: Two PET scans, one of each with [11C]PIB and [18F]FACT, were performed sequentially on six normal control subjects, two mild cognitive impairment (MCI) patients, and six AD patients. The standardized uptake value ratio of brain regions to the cerebellum was calculated with partial volume correction using magnetic resonance (MR) images to remove the effects of white matter accumulation. Results: No significant differences in the cerebral cortical uptake were observed between normal control subjects and AD patients in [18F]FACT studies without partial volume correction, while significant differences were observed in [11C]PIB. After partial volume correction, the cerebral cortical uptake was significantly larger in AD patients than in normal control subjects for [18F]FACT studies as well as [11C]PIB. Relatively lower uptakes of [11C]PIB in distribution were observed in the medial side of the temporal cortex and in the occipital cortex as compared with [18F]FACT. Relatively higher uptake of [11C]PIB in distribution was observed in the frontal and parietal cortices. Conclusion: Since [18F]FACT might bind more preferentially to dense-cored amyloid deposition, regional differences in cerebral cortical uptake between [11C]PIB and [18F]FACT might be due to differences in regional distribution between diffuse and dense-cored amyloid plaque shown in the autoradiographic and histochemical assays of postmortem AD brain sections.

Original languageEnglish
Pages (from-to)745-754
Number of pages10
JournalEuropean journal of nuclear medicine and molecular imaging
Volume41
Issue number4
DOIs
Publication statusPublished - 2014 Apr

Keywords

  • Alzheimer
  • Amyloid
  • FACT
  • PET
  • PIB

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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