Noninvasive measurement of amyloid deposition is potentially useful for early and accurate diagnosis of dementia and for pharmacological evaluation of anti-amyloid therapy. To evaluate the clinical utility of BF-227 as an amyloid imaging probe, we performed PBT study using [11C]BF-227 in the patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) . AD patients showed significant retention of [11C]BF-227 in the prefrontal, temporal and posterior association cortex. In addition, about 66% of MCI subjects also showed cortical retention of BF-227. These results indicate that BF-227 is useful for in vivo detection of senile plaques in the brain.
|Number of pages||9|
|Journal||Japanese Journal of Clinical Radiology|
|Publication status||Published - 2008 Aug 5|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging