Imaging amyloid deposits in the brain using [11C] BF-227

Nobuyuki Okamura

Research output: Contribution to journalArticlepeer-review

Abstract

Noninvasive measurement of amyloid deposition is potentially useful for early and accurate diagnosis of dementia and for pharmacological evaluation of anti-amyloid therapy. To evaluate the clinical utility of BF-227 as an amyloid imaging probe, we performed PBT study using [11C]BF-227 in the patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) . AD patients showed significant retention of [11C]BF-227 in the prefrontal, temporal and posterior association cortex. In addition, about 66% of MCI subjects also showed cortical retention of BF-227. These results indicate that BF-227 is useful for in vivo detection of senile plaques in the brain.

Original languageEnglish
Pages (from-to)876-884
Number of pages9
JournalJapanese Journal of Clinical Radiology
Volume53
Issue number7
Publication statusPublished - 2008 Aug 5

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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