Abstract
Noninvasive measurement of amyloid deposition is potentially useful for early and accurate diagnosis of dementia and for pharmacological evaluation of anti-amyloid therapy. To evaluate the clinical utility of BF-227 as an amyloid imaging probe, we performed PBT study using [11C]BF-227 in the patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) . AD patients showed significant retention of [11C]BF-227 in the prefrontal, temporal and posterior association cortex. In addition, about 66% of MCI subjects also showed cortical retention of BF-227. These results indicate that BF-227 is useful for in vivo detection of senile plaques in the brain.
Original language | English |
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Pages (from-to) | 876-884 |
Number of pages | 9 |
Journal | Japanese Journal of Clinical Radiology |
Volume | 53 |
Issue number | 7 |
Publication status | Published - 2008 Aug 5 |
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging