Illusory misidentifications and cortical hypometabolism in Parkinson's disease

Toshiyuki Ishioka, Kazumi Hirayama, Yoshiyuki Hosokai, Atsushi Takeda, Kyoko Suzuki, Yoshiyuki Nishio, Yoichi Sawada, Syouki Takahashi, Hiroshi Fukuda, Yasuto Itoyama, Etsuro Mori

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Idiopathic Parkinson's disease (PD) is associated with documented impairments in various visual functions. However, there have been only a limited number of studies that have reported on the brain regions responsible for impairment of visual recognition in PD. In our study, we evaluated the performance of PD patients and 24 healthy controls on the Poppelreuter-type overlapping figure identification test to investigate the impairment of visual recognition. We also measured the PD patients' resting cerebral glucose metabolism using 18F-fluorodeoxyglucose positron emission tomography and investigated the relationship between the impairment of visual recognition and cortical hypometabolism. The PD patients had substantial and frequent illusory responses in the overlapping figure identification test, and their illusory misidentifications were correlated with hypometabolism in the visual cortices, including the right inferior temporal gyrus and the bilateral temporo-parieto-occipital junction. These findings suggest that PD patients have impaired visual recognition characterized by illusory misidentifications of visual stimuli, which could be attributed to dysfunction of the visual cortices.

Original languageEnglish
Pages (from-to)837-843
Number of pages7
JournalMovement Disorders
Volume26
Issue number5
DOIs
Publication statusPublished - 2011 Apr 1

Keywords

  • Illusory misidentification
  • Overlapping figure identification test
  • Parkinson's disease
  • Positron emission tomography
  • Visual cortices

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Ishioka, T., Hirayama, K., Hosokai, Y., Takeda, A., Suzuki, K., Nishio, Y., Sawada, Y., Takahashi, S., Fukuda, H., Itoyama, Y., & Mori, E. (2011). Illusory misidentifications and cortical hypometabolism in Parkinson's disease. Movement Disorders, 26(5), 837-843. https://doi.org/10.1002/mds.23576