Illuminating G-Protein-Coupling Selectivity of GPCRs

Asuka Inoue, Francesco Raimondi, Francois Marie Ngako Kadji, Gurdeep Singh, Takayuki Kishi, Akiharu Uwamizu, Yuki Ono, Yuji Shinjo, Satoru Ishida, Nadia Arang, Kouki Kawakami, J. Silvio Gutkind, Junken Aoki, Robert B. Russell

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A large-scale functional interaction study reveals how GPCRs engage with subsets of G(alpha) proteins and outlines characteristic predictive of these associations.

Original languageEnglish
Pages (from-to)1933-1947.e25
JournalCell
Volume177
Issue number7
DOIs
Publication statusPublished - 2019 Jun 13

Keywords

  • DREADD
  • G-protein-coupled receptors
  • HEK293 cells
  • NanoBiT
  • TGF-α shedding assay
  • bioinformatics
  • chimeric G protein
  • prediction
  • protein design
  • signaling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Inoue, A., Raimondi, F., Kadji, F. M. N., Singh, G., Kishi, T., Uwamizu, A., Ono, Y., Shinjo, Y., Ishida, S., Arang, N., Kawakami, K., Gutkind, J. S., Aoki, J., & Russell, R. B. (2019). Illuminating G-Protein-Coupling Selectivity of GPCRs. Cell, 177(7), 1933-1947.e25. https://doi.org/10.1016/j.cell.2019.04.044