TY - JOUR
T1 - IL-17A produced by γδ T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver
AU - Hamada, Satoru
AU - Umemura, Masayuki
AU - Shiono, Takeru
AU - Tanaka, Kensho
AU - Yahagi, Ayano
AU - Begum, M. Dilara
AU - Oshiro, Kiyotetsu
AU - Okamoto, Yuko
AU - Watanabe, Hisami
AU - Kawakami, Kazuyoshi
AU - Roark, Christina
AU - Born, Willi K.
AU - O'Brien, Rebecca
AU - Ikuta, Koichi
AU - Ishikawa, Hiromichi
AU - Nakae, Susumu
AU - Iwakura, Yoichiro
AU - Ohta, Takao
AU - Matsuzaki, Goro
PY - 2008/9/1
Y1 - 2008/9/1
N2 - IL-17A is originally identified as a proinflammatory cytokine that induces neutrophils. Although IL-17A production by CD4+ Th17 T cells is well documented, it is not clear whether IL-17A is produced and participates in the innate immune response against infections. In the present report, we demonstrate that IL-17A is expressed in the liver of mice infected with Listeria monocytogenes from an early stage of infection. IL-17A is important in protective immunity at an early stage of listerial infection in the liver because IL-17A-deficient mice showed aggravation of the protective response. The major IL-17A-producing cells at the early stage were TCR γδ T cells expressing TCR Vγ4 or Vγ6. Interestingly, TCR γδ T cells expressing both IFN-γ and IL-17A were hardly detected, indicating that the IL-17A-producing TCR γδ T cells are distinct from IFN-γ-producing γδ T cells, similar to the distinction between Th17 and Th1 in CD4+ T cells. All the results suggest that IL-17A is a newly discovered effector molecule produced by TCR γδ T cells, which is important in innate immunity in the liver.
AB - IL-17A is originally identified as a proinflammatory cytokine that induces neutrophils. Although IL-17A production by CD4+ Th17 T cells is well documented, it is not clear whether IL-17A is produced and participates in the innate immune response against infections. In the present report, we demonstrate that IL-17A is expressed in the liver of mice infected with Listeria monocytogenes from an early stage of infection. IL-17A is important in protective immunity at an early stage of listerial infection in the liver because IL-17A-deficient mice showed aggravation of the protective response. The major IL-17A-producing cells at the early stage were TCR γδ T cells expressing TCR Vγ4 or Vγ6. Interestingly, TCR γδ T cells expressing both IFN-γ and IL-17A were hardly detected, indicating that the IL-17A-producing TCR γδ T cells are distinct from IFN-γ-producing γδ T cells, similar to the distinction between Th17 and Th1 in CD4+ T cells. All the results suggest that IL-17A is a newly discovered effector molecule produced by TCR γδ T cells, which is important in innate immunity in the liver.
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U2 - 10.4049/jimmunol.181.5.3456
DO - 10.4049/jimmunol.181.5.3456
M3 - Article
C2 - 18714018
AN - SCOPUS:51549115916
VL - 181
SP - 3456
EP - 3463
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 5
ER -