IL-17A produced by γδ T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver

Satoru Hamada, Masayuki Umemura, Takeru Shiono, Kensho Tanaka, Ayano Yahagi, M. Dilara Begum, Kiyotetsu Oshiro, Yuko Okamoto, Hisami Watanabe, Kazuyoshi Kawakami, Christina Roark, Willi K. Born, Rebecca O'Brien, Koichi Ikuta, Hiromichi Ishikawa, Susumu Nakae, Yoichiro Iwakura, Takao Ohta, Goro Matsuzaki

Research output: Contribution to journalArticlepeer-review

255 Citations (Scopus)

Abstract

IL-17A is originally identified as a proinflammatory cytokine that induces neutrophils. Although IL-17A production by CD4+ Th17 T cells is well documented, it is not clear whether IL-17A is produced and participates in the innate immune response against infections. In the present report, we demonstrate that IL-17A is expressed in the liver of mice infected with Listeria monocytogenes from an early stage of infection. IL-17A is important in protective immunity at an early stage of listerial infection in the liver because IL-17A-deficient mice showed aggravation of the protective response. The major IL-17A-producing cells at the early stage were TCR γδ T cells expressing TCR Vγ4 or Vγ6. Interestingly, TCR γδ T cells expressing both IFN-γ and IL-17A were hardly detected, indicating that the IL-17A-producing TCR γδ T cells are distinct from IFN-γ-producing γδ T cells, similar to the distinction between Th17 and Th1 in CD4+ T cells. All the results suggest that IL-17A is a newly discovered effector molecule produced by TCR γδ T cells, which is important in innate immunity in the liver.

Original languageEnglish
Pages (from-to)3456-3463
Number of pages8
JournalJournal of Immunology
Volume181
Issue number5
DOIs
Publication statusPublished - 2008 Sep 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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