IL-12 receptor β2 and CD30 expression in paranasal sinus mucosa of patients with chronic sinusitis

H. Suzuki, S. Goto, K. Ikeda, T. Oshima, M. Furukawa, T. Takasaka

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9 Citations (Scopus)


The aetiology of chronic sinusitis is still poorly uuderstood. The expression of T-helper 1 (Th1) and T-helper 2 (Th2) cell markers, interleukin (IL)-12 receptor β2 subunit (IL-12Rβ2) messenger ribonucleic acid (mRNA) and CD30, respectively, were investigated in the paranasal sinus mucosa of patients with chronic sinusitis in an attempt to elucidate the involvement of Th1 and Th2 cells in this disease. Anterior ethmoidal mucosae were surgically obtained from two groups of patients with chronic sinusitis: those who had allergic rhinitis (allergic group, n=11) and those without allergy (nonallergic group, n=11). IL-12Rβ2 mRNA was quantified by means of the reverse transcription polymerase chain reaction, and CD30-positive cells were examined immunohistochemically. Both IL-12Rβ2 mRNA and CD30 were expressed in the sinus mucosa of the allergic and nonallergic groups. The proportion of mononuclear cells which were CD30-positive in the sinus mucosa was significantly greater in the allergic than in the nonallergic group. The expression levels of IL-12Rβ2 mRNA were virtually equivalent in both groups. These results suggest a T-helper 2-dominated mucosal reaction in the allergic compared to the nonallergic group, and indicate T-helper 1 activity in the sinus mucosa of both groups. The ubiquity of T-helper 1 cells suggests that they play a role in maintaining local mucosal defences against foreign antigens, which continually enter the upper respiratory tract.

Original languageEnglish
Pages (from-to)1008-1013
Number of pages6
JournalEuropean Respiratory Journal
Issue number5
Publication statusPublished - 1999
Externally publishedYes


  • CD30
  • Chronic sinusitis
  • Interleukin-12 receptor β subunit
  • T-helper 1- T-helper 2 balance

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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