IL-10 gene polymorphism, but not TGF-β1 gene polymorphisms, is associated with food allergy in a Japanese population

Eduardo Jose Campos Alberto, Naoki Shimojo, Yoichi Suzuki, Yoichi Mashimo, Takayasu Arima, Tomoko Matsuura, Yuzaburo Inoue, Akiko Yamaide, Minako Tomiita, Katsunori Fujii, Akira Hata, Yoichi Kohno

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The regulatory IL-10 and TGF-β1 cytokine gene polymorphisms have been associated with allergic diseases in different populations, like Caucasian, Chinese and Indians. We investigated the association between the polymorphisms IL-10 A-1082G, C-819T, C-627A and TGF-β1 T+869C, G+915C, C-509T and food allergy in Japanese children. One hundred and eleven children with food allergy and 115 atopic control children without food allergy were recruited. DNA samples from these subjects were genotyped by using PCR. The odds ratio of IL-10 -1082 AA genotype was 2.5 (95% CI, 1.0-6.4) for food allergy risk when compared with atopic control subjects (p = 0.03). There were no significative differences in the frequency of TGF-β1 gene polymorphisms between both groups. Our results indicate that IL-10 A-1082G gene polymorphism is associated with food allergy susceptibility in atopic Japanese children.

Original languageEnglish
Pages (from-to)716-721
Number of pages6
JournalPediatric Allergy and Immunology
Volume19
Issue number8
DOIs
Publication statusPublished - 2008 Dec 1

Keywords

  • Food allergy
  • Gene
  • IL-10
  • Polymorphism
  • TGF-β1
  • Transcription factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

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