Idiopathic normal pressure hydrocephalus

Etsuro Mori

Research output: Contribution to journalArticlepeer-review

Abstract

Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome characterized by gait disturbance, dementia, and/or urinary incontinence without causative disorders, and ventricular enlargement due to disturbed CSF circulation. The diagnosis of iNPH in the elderly remains a substantial issue, and the treatment is not always adequately provided. Many patients with possibly curable INPH often are misdiagnosed as having AD or vascular dementia. Recognition of INPH in those patients is of great importance. Here, some key clinical and neuroimaging features distinctive from other dementia are discussed. Also reviewed are the results of the recently completed prospective cohort study of iNPH (Study of iNPH on Neurological Improvement: SINPHONI). In SINPHONI, the MRI-based diagnosis (dilated ventricles associated with narrow dorsal subarachnoid space) and ventriculoperitoneal shunt with Codman Hakim programmable valve shunt system were validated against 1-year post-surgery outcome.

Original languageEnglish
Pages (from-to)945-947
Number of pages3
JournalClinical Neurology
Volume47
Issue number11
Publication statusPublished - 2007 Nov

Keywords

  • Clinical trial
  • Diagnosis
  • Idiopathic normal pressure hydrocephalus
  • MRI
  • Neurology

ASJC Scopus subject areas

  • Clinical Neurology

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