TY - JOUR
T1 - Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan
T2 - A Research Example from the Japanese Gerontological Evaluation Study
AU - Cable, N.
AU - Hiyoshi, A.
AU - Kondo, N.
AU - Aida, J.
AU - Sjöqvist, H.
AU - Kondo, K.
N1 - Funding Information:
This study is supported by the UK Economic and Social Research Council (ESRC, ES/J019119/1) and the Research Committee of Örebro County Council (OLL-346981). This study used data from the Japanese Gerontological Evaluation Study (JAGES), which was supported by the MEXT (Ministry of Education, Culture, Sports, Science and Technology, Japan) Supported Program for the Strategic Research Foundation at Private Universities (2009–2013), JSPS (Japan Society for the Promotion of Science) KAKENHI Grants (JP22330172, JP22390400, JP23243070, JP23590786, JP23790710, JP24390469, JP24530698, JP24683018, JP25253052, JP25870573, and JP25870881), Health Labour Sciences Research Grants (H22-Choju-Shitei-008, H24-Junkanki[Seishu]-Ippan-007, H24-Chikyukibo-Ippan-009, H24-Choju-Wakate-009, H25-Kenki-Wakate-015, H26-Irryo-Shitei-003[Fukkou], H25-Choju-Ippan-003, and H26-Choju-Ippan-006) from the Japan Ministry of Health, Labour and Welfare, the Research and Development Grants for Longevity Science from the AMED (Japan Agency for Medical Research and Development), and a grant from the National Centre for Geriatrics and Gerontology, Japan (24-17, 24-23). The authors thank Ms. Virginia Rounding for proofreading.
PY - 2018
Y1 - 2018
N2 - We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants (N = 3,128) who also participated in the community health screening in 2010. We grouped participants' response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1.99, 95% CI = 1.22-3.23; RRR = 1.36, 95% CI = 1.33-1.39; RRR = 1.36, 95% CI = 1.23-1.51, resp.) and frail cases (RRR = 2.27, 95% CI = 1.91-2.70; RRR = 1.59, 95% CI = 1.51-1.68; RRR = 1.40, 95% CI = 1.28-1.52, resp.). Limited to women, above normal Hb1Ac level was similarly associated with intermediate frail and frail cases (RRR = 1.18, 95% CI = 1.02, 1.38; RRR = 2.56, 95% CI = 2.23-2.95, resp.). Use of relevant clinical biomarkers can help in assessment of older adults' physical aspect of frailty.
AB - We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants (N = 3,128) who also participated in the community health screening in 2010. We grouped participants' response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1.99, 95% CI = 1.22-3.23; RRR = 1.36, 95% CI = 1.33-1.39; RRR = 1.36, 95% CI = 1.23-1.51, resp.) and frail cases (RRR = 2.27, 95% CI = 1.91-2.70; RRR = 1.59, 95% CI = 1.51-1.68; RRR = 1.40, 95% CI = 1.28-1.52, resp.). Limited to women, above normal Hb1Ac level was similarly associated with intermediate frail and frail cases (RRR = 1.18, 95% CI = 1.02, 1.38; RRR = 2.56, 95% CI = 2.23-2.95, resp.). Use of relevant clinical biomarkers can help in assessment of older adults' physical aspect of frailty.
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U2 - 10.1155/2018/5362948
DO - 10.1155/2018/5362948
M3 - Article
C2 - 29607322
AN - SCOPUS:85041725243
VL - 2018
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
M1 - 5362948
ER -