Identification of two teleost homologs of the Drosophila sex determination factor, transformer-2 in medaka (Oryzias latipes)

Eri Shiraishi, Hideo Imazato, Takashi Yamamoto, Hayato Yokoi, Shin Ichi Abe, Takeshi Kitano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Transformer-2 (Tra2), an RNA-binding protein, is an important regulator in Drosophila sex determination. In vertebrates, however, the role of Tra2 homologues is not known. We identified two teleost homologues of Tra2, which we named Tra2a and Tra2b, in medaka (Oryzias latipes). Furthermore, we demonstrated that both Tra2 mRNAs were predominantly expressed in germ cells of both sexes before the onset of sex differentiation, suggesting that both Tra2 homologues might be involved in the sex differentiation in medaka.

Original languageEnglish
Pages (from-to)991-996
Number of pages6
JournalMechanisms of Development
Volume121
Issue number7-8
DOIs
Publication statusPublished - 2004 Jul 1
Externally publishedYes

Keywords

  • Germ cell
  • Medaka
  • Sex differentiation
  • Teleost
  • Tra2
  • Transformer-2

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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