Identification of two rodent genes encoding homologues to seminal vesicle autoantigen: A gene family including the gene for prolactin-inducible protein

Masato Yoshida, Mika Kaneko, Hirohisa Kurachi, Motoki Osawa

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We cloned two new paralogous genes that encode proteins homologous to seminal vesicle autoantigen (SVA) in rodents. The open reading frame of one mouse gene encodes a polypeptide consisting of 151 amino acid residues which has 43% identity to SVA. RT-PCR analysis showed selective expression in the colon, and thus the protein was tentatively named "SVA-like protein in the colon (SLP-C)". The other mouse gene has an open reading frame encoding 144 amino acid residues with 46 and 65% identity to SVA and SLP-C, respectively. Expression of this gene was detected in the mammary, submaxillary, parotid, and lacrimal glands, and this protein was named "SLP in the mammary gland (SLP-M)". Orthologs of both genes were also found in rats. The three homologous genes coding for SVA, SLP-C, and SLP-M may have been generated by gene duplication with divergence of tissue expression in the course of evolution. They comprise a unique structurally-related gene family. Moreover, these genes share significant sequence homology with that of another secretory glycoprotein, prolactin-inducible protein.

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalBiochemical and biophysical research communications
Volume281
Issue number1
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

Keywords

  • Exocrine organs
  • Gene duplication
  • Prolactin-inducible protein
  • Seminal vesicle autoantigen

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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