Abstract
The nuclear receptor CAR, a phenobarbital (PB)-responsive transcription factor, translocates into the nucleus of hepatocytes after PB induction. In non-induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the CAR:HSP90 complex. This recruitment may lead CAR to translocate into the nucleus, consistent with the inhibitions of nuclear CAR accumulation in PB-induced mouse primary hepatocytes by okadaic acid as well as by geldanamycin.
Original language | English |
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Pages (from-to) | 17-20 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 548 |
Issue number | 1-3 |
DOIs | |
Publication status | Published - 2003 Jul 31 |
Keywords
- Heat shock protein
- Nuclear receptor CAR
- Nuclear translocation
- Phenobarbital
- Protein phosphatase
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology