Identification of ST2A1 as a rat brain neurosteroid sulfotransferase mRNA

Miki Shimada, Kouichi Yoshinari, Emi Tanabe, Emi Shimakawa, Maki Kobashi, Kiyoshi Nagata, Yasushi Yamazoe

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

A hydroxysteroid sulfotransferase (ST2A1) was identified as a form mediating neurosteroid sulfation in rat brain. The sole expression among known rat ST2A forms was indicated by brain RT-PCR. All nucleotide sequences of seven ST2A cDNA clones isolated from brain matched completely with that of hepatic ST2A1. The recombinant ST2A1 protein mediated neurosteroid sulfation. These data strongly suggest a functional role of ST2A1 as a neurosteroid sulfotransferase in rat brain.

Original languageEnglish
Pages (from-to)222-225
Number of pages4
JournalBrain research
Volume920
Issue number1-2
DOIs
Publication statusPublished - 2001 Nov 30

Keywords

  • Neurosteroid
  • ST2A1
  • Sulfate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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