Identification of protein tyrosine phosphatases expressed in murine male germ cells

Yoshiyuki Kaneko, Seiichiro Takano, Kazuhiro Okumura, Jun Takenawa, Hiroaki Higashituji, Manabu Fukumoto, Hiroki Nakayama, Jun Fujita

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


We cloned five cDNAs encoding putative protein tyrosine phosphatases (PTPs; protein-tyrosine-phosphatase phosphohydrolase, EC from the murine testis by using degenerate primers and the polymerase chain reaction cloning technique. Two of them were identical to the mouse cytoplasmic PTP and PTP-1B. The remaining three were likely to represent the murine counterparts of human FTP δ, human FTP ε(lunate), and rat striatum-enriched PTP. The cells expressing these genes were determined either by in situ hybridization histochemistry or by Northern blot hybridization. Moreover, Northern blot hybridization revealed that the transcripts of FTP-1B, mouse cytoplasmic FTP and the murine homologue of human PTP δ were quantitatively and/or structurally regulated during germ cell development, suggesting their roles in spermatogenesis.

Original languageEnglish
Pages (from-to)625-631
Number of pages7
JournalBiochemical and biophysical research communications
Issue number2
Publication statusPublished - 1993 Dec 15

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Identification of protein tyrosine phosphatases expressed in murine male germ cells'. Together they form a unique fingerprint.

Cite this