Identification of novel norovirus polymerase genotypes from pediatric fecal samples collected between the year 1997 and 2000 in Japan

Mohan Amarasiri, Etsuko Utagawa, Daisuke Sano, Kazuhiko Katayama

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed 46 pediatric fecal samples collected between the years 1997 and 2000 to retrospectively evaluate the norovirus strains circulating during that era and to identify possible re-emergence patterns. From the tested fecal samples, we detected GII.1, GII.3, GII.4 (95/96-US) and GII.6 strains. Most importantly, two novel polymerase genotypes (GI.PNA4 and GII.PNA7) were detected during the study. Two possible recombinant strains (GII.6[P7] and GII.3[P29]) were identified and SimPlot analysis confirmed that GII.6[P7] is a recombinant strain. The study emphasizes the importance of retrospective evaluation of human fecal samples in obtaining a better understanding of norovirus circulation, re-emergence and evolution.

Original languageEnglish
Article number104313
JournalInfection, Genetics and Evolution
Volume82
DOIs
Publication statusPublished - 2020 Aug

Keywords

  • Evolution
  • Norovirus
  • Novel polymerase genotypes
  • Re-emergence
  • Retrospective analysis

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

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