Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion

Mio Yano, Toshihiko Imamura, Daisuke Asai, Nobutaka Kiyokawa, Kazuhiko Nakabayashi, Kenji Matsumoto, Takao Deguchi, Yoshiko Hashii, Yu ko Honda, Daiichiro Hasegawa, Yoji Sasahara, Mutsuo Ishii, Yoshiyuki Kosaka, Koji Kato, Midori Shima, Hiroki Hori, Keiko Yumura-Yagi, Junichi Hara, Megumi Oda, Keizo HoribeHitoshi Ichikawa, Atsushi Sato

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Activating tyrosine kinase mutations or cytokine receptor signalling alterations have attracted attention as therapeutic targets for high-risk paediatric acute lymphoblastic leukaemia (ALL). We identified two novel kinase fusions, OFD1-JAK2 and NCOR1-LYN, in paediatric ALL patients with IKZF1 deletion, by mRNA sequencing. The patient with CSF2RA-CRLF2 also harboured IGH-EPOR. All these patients had high-risk features, such as high initial white blood cell counts and initial poor response to prednisolone. The functional analysis of these novel fusions is on-going to determine whether these genetic alterations can be targeted by drugs.

Original languageEnglish
Pages (from-to)813-817
Number of pages5
JournalBritish Journal of Haematology
Volume171
Issue number5
DOIs
Publication statusPublished - 2015 Dec 1

Keywords

  • IKZF1
  • Kinase fusion
  • Paediatric ALL
  • Ph-like ALL

ASJC Scopus subject areas

  • Hematology

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    Yano, M., Imamura, T., Asai, D., Kiyokawa, N., Nakabayashi, K., Matsumoto, K., Deguchi, T., Hashii, Y., Honda, Y. K., Hasegawa, D., Sasahara, Y., Ishii, M., Kosaka, Y., Kato, K., Shima, M., Hori, H., Yumura-Yagi, K., Hara, J., Oda, M., ... Sato, A. (2015). Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion. British Journal of Haematology, 171(5), 813-817. https://doi.org/10.1111/bjh.13757