Identification of Mycobacterium avium Complex Isolated in Eastern and Central Japan by Using DNA Probes

Akira Watanabe, Hiroaki Kikuchi, Satoru Shoji, Toshihiro Nukiwa, Masakichi Motomiya, Tsukasa Yoshida, Shigeo Takizawa, Kotaro Oizumi

    Research output: Contribution to journalArticlepeer-review

    Abstract

    WATANABE, A., KIKUCHI, H., SHOJI, S., NUKIWA, T., MOTOMIYA, M., YOSHIDA, T., TAKIZAWAS., and OIZUMIK,. Identification of Mycobacterium avium Complex Isolated in Eastern and Central Japan by Using DNA Probes. Tohoku J. Exp. Med., 1995, 175 (2),139-142—An attempt was made to identify Mycobacterium avium and Mycobacterium intracellulare in the M. avium intracellulare complex (MAC) isolatad in the Tohoku (38 strains) and Tokai (30 strains) districts of Japan by using DNA probes which are specific for M. avium, M. intracellulare and M. tuberculosis complex, respectively. The incidence of M. avium infection (82%) by far exceeded that of M. intracellulare infection in the Tohoku district of eastern Japan. In the Tokai district of central Japan, the incidence of M. avium infection (57%) were slightly larger than that of M. intracellulare infection. Five of 68 strains showed a positive reaction with two different DNA probes. Thus a possibility of mixed infection could not be ruled out, because reference strains showed a positive reaction with only one species-specific DNA probe.

    Original languageEnglish
    Pages (from-to)139-142
    Number of pages4
    JournalTohoku Journal of Experimental Medicine
    Volume175
    Issue number2
    DOIs
    Publication statusPublished - 1995

    Keywords

    • DNA probe
    • M. avium
    • M. avium intracellulare complex
    • M. intracellulare

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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