Abstract
Liver X receptor alpha (LXRα) is a member of the nuclear receptor superfamily that is activated by oxysterols, and plays a pivotal role in regulating the metabolism, transport and uptake of cholesterol. Here, we demonstrate that LXRα also regulates the low-density lipoprotein receptor (LDLR) gene, which mediates the endocytic uptake of LDL cholesterol in the liver. An LXR agonist induced the expression of LDLR in cultured hepatoblastoma cells. Moreover, the LDLR promoter contained an LXR response element that was recognized by LXRα/RXRα (retinoid X receptor alpha) heterodimers in hepatoblastoma cells. These results suggest a novel pathway whereby LXRα might modulate cholesterol metabolism.
Original language | English |
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Pages (from-to) | 4929-4933 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 580 |
Issue number | 20 |
DOIs | |
Publication status | Published - 2006 Sep 4 |
Externally published | Yes |
Keywords
- Cholesterol
- LXR response element
- Liver X receptor
- Low-density lipoprotein receptor
- Nuclear receptor
- SREBP
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology