Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha

Kenji Ishimoto, Keisuke Tachibana, Mikako Sumitomo, Shiho Omote, Ikuko Hanano, Daisuke Yamasaki, Yuichiro Watanabe, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Takefumi Doi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Liver X receptor alpha (LXRα) is a member of the nuclear receptor superfamily that is activated by oxysterols, and plays a pivotal role in regulating the metabolism, transport and uptake of cholesterol. Here, we demonstrate that LXRα also regulates the low-density lipoprotein receptor (LDLR) gene, which mediates the endocytic uptake of LDL cholesterol in the liver. An LXR agonist induced the expression of LDLR in cultured hepatoblastoma cells. Moreover, the LDLR promoter contained an LXR response element that was recognized by LXRα/RXRα (retinoid X receptor alpha) heterodimers in hepatoblastoma cells. These results suggest a novel pathway whereby LXRα might modulate cholesterol metabolism.

Original languageEnglish
Pages (from-to)4929-4933
Number of pages5
JournalFEBS Letters
Volume580
Issue number20
DOIs
Publication statusPublished - 2006 Sep 4
Externally publishedYes

Keywords

  • Cholesterol
  • LXR response element
  • Liver X receptor
  • Low-density lipoprotein receptor
  • Nuclear receptor
  • SREBP

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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