Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis

Risa Masumoto, Jirouta Kitagaki, Chiharu Fujihara, Masahiro Matsumoto, Shizuka Miyauchi, Yoshihiro Asano, Atsuko Imai, Kaori Kobayashi, Akihiro Nakaya, Motozo Yamashita, Satoru Yamada, Masahiro Kitamura, Shinya Murakami

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

To identify the genetic risk factors for aggressive periodontitis (AgP), it is important to understand the progression and pathogenesis of AgP. The purpose of this review was to summarize the genetic risk factors for AgP identified through a case-control genomewide association study (GWAS) and replication study. The initial studies to identify novel AgP risk factors were potentially biased because they relied on previous studies. To overcome this kind of issue, an unbiased GWAS strategy was introduced to identify genetic risk factors for various diseases. Currently, three genes glycosyltransferase 6 domain containing 1 (GLT6D1), defensin α1 and α3 (DEFA1A3), and sialic acid-binding Ig-like lectin 5 (SIGLEC5) that reach the threshold for genomewide significance have been identified as genetic risk factors for AgP through a case-control GWAS.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalJournal of Periodontal Research
Volume54
Issue number3
DOIs
Publication statusPublished - 2019 Jun

Keywords

  • aggressive periodontitis
  • chronic periodontitis
  • genetic risk factor
  • genomewide association study
  • genomewide significance threshold
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Periodontics

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