Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system

Yasuyuki Kida, Tomoki Shiraishi, Toshihiko Ogura

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Genes controlling the planar cell polarity (PCP) pathway have recently been described in Drosophila. Although a number of PCP-related genes were identified, it remains unknown whether the same genetic programs found in invertebrate embryos operate in vertebrate embryos, especially with regard to central nervous system development. To gain insights into the roles played by vertebrate PCP-related genes, we cloned and examined the expression patterns of chick and mouse homologues of the Xenopus Daam gene, an essential component of the PCP pathway and involved in the convergent extension movement of cells. The observed expression patterns in developing central nervous tissues suggested that vertebrate Daam genes were involved in pivotal steps in neuronal cell differentiation and movement.

Original languageEnglish
Pages (from-to)143-150
Number of pages8
JournalDevelopmental Brain Research
Volume153
Issue number1
DOIs
Publication statusPublished - 2004 Oct 15

Keywords

  • Brain
  • Daam
  • Migration
  • Planar cell polarity
  • Spinal cord

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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