Identification of cDNA coding for a homologue to mammalian leptin from pufferfish, Takifugu rubripes

Tadahide Kurokawa, Susumu Uji, Tohru Suzuki

    Research output: Contribution to journalArticlepeer-review

    194 Citations (Scopus)

    Abstract

    We identified cDNA coding for a homologue to mammalian leptin in puffer, Takifugu rubripes, using genomic synteny around the human leptin gene. In addition to significant sequence homologies, the puffer leptin (pLEP) displays characteristic structural features in common with mammalian leptin. The pLEP mRNA was expressed mostly in the liver that contained abundant lipids. In addition, homologues to pLEP were found in the databanks for three fish species (salmon, medaka, and Tetraodon) and two amphibians (salamander and Xenopus). The phylogenetic analysis shows rapid rates of molecular divergence among leptins from different vertebrate classes, but not between mammals and avians.

    Original languageEnglish
    Pages (from-to)745-750
    Number of pages6
    JournalPeptides
    Volume26
    Issue number5
    DOIs
    Publication statusPublished - 2005 May

    Keywords

    • Amphibian
    • Fish
    • Leptin
    • Takifugu rubripes
    • cDNA

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Endocrinology
    • Cellular and Molecular Neuroscience

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