Identification of advanced glycation end products of the Maillard reaction in Pick's disease

Takemi Kimura, Kazuyoshi Ikeda, Junichi Takamatsu, Toshio Miyata, Gen Sobue, Taihei Miyakawa, Seikoh Horiuchi

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

The recent identification of advanced glycation end products (AGEs) of the Maillard reaction in the central nervous system suggests their potential involvement in the aging process. Other studies have also suggested a possible link between AGEs and Alzheimer's disease, To investigate the role of AGEs in Pick's disease, another neurodegenerative disease associated with dementia, we examined the AGE-immunoreaction in Pick's bodies and ballooned neurons, two characteristic neuropathological features of Pick's disease, using antibodies against identified AGE-structures, N(ε)-(carboxymethyl)lysine and pentosidine. These two structures were observed immunohistochemically in Pick's bodies and ballooned neurons of brain tissues obtained at autopsy from three elderly patients diagnosed with Pick's disease. These immunoreactions were further confirmed by absorption experiments and double-immunostaining. The present findings suggest that AGEs are involved in the pathology of Pick's disease.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalNeuroscience Letters
Volume219
Issue number2
DOIs
Publication statusPublished - 1996 Nov 22
Externally publishedYes

Keywords

  • Advanced glycation end products
  • Alzheimer's disease
  • Ballooned neurons
  • N(ε)-(Carboxymethyl)lysine
  • Pentosidinee
  • Pick's bodies
  • Pick's disease

ASJC Scopus subject areas

  • Neuroscience(all)

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