Abstract
Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3,7,8- tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants.
Original language | English |
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Pages (from-to) | 20-25 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 13 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1999 Jan 1 |
Externally published | Yes |
Keywords
- AhR
- Amt
- TCDD
- XRE
- bHLH-PAS
ASJC Scopus subject areas
- Genetics
- Developmental Biology