Identification of a novel mechanism of regulation of Ah (dioxin) receptor function

Junsei Mimura, Masatsugu Ema, Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama

Research output: Contribution to journalArticlepeer-review

426 Citations (Scopus)

Abstract

Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3,7,8- tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalGenes and Development
Volume13
Issue number1
DOIs
Publication statusPublished - 1999 Jan 1
Externally publishedYes

Keywords

  • AhR
  • Amt
  • TCDD
  • XRE
  • bHLH-PAS

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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