Identification of a novel mechanism of regulation of Ah (dioxin) receptor function

Junsei Mimura, Masatsugu Ema, Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama

    Research output: Contribution to journalArticlepeer-review

    401 Citations (Scopus)

    Abstract

    Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3,7,8- tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants.

    Original languageEnglish
    Pages (from-to)20-25
    Number of pages6
    JournalGenes and Development
    Volume13
    Issue number1
    DOIs
    Publication statusPublished - 1999 Jan 1

    Keywords

    • AhR
    • Amt
    • TCDD
    • XRE
    • bHLH-PAS

    ASJC Scopus subject areas

    • Genetics
    • Developmental Biology

    Fingerprint Dive into the research topics of 'Identification of a novel mechanism of regulation of Ah (dioxin) receptor function'. Together they form a unique fingerprint.

    Cite this