Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

Abe Takaaki, Masayuki Kakyo, Taro Tokui, Rie Nakagomi, Toshiyuki Nishio, Daisuke Nakai, Hideki Nomura, Michiaki Unno, Masanori Suzuki, Takeshi Naitoh, Seiki Matsuno, Hiromu Yawo

Research output: Contribution to journalArticlepeer-review

465 Citations (Scopus)

Abstract

We have isolated a novel liver-specific organic anion transporter, LST- 1, that is expressed exclusively in the human, rat, and mouse liver. LST-1 is a new gene family located between the organic anion transporter family and prostaglandin transporter. LST-1 transports taurocholate (K(m) = 13.6 μM) in a sodium-independent manner. LST-1 also shows broad substrate specificity. It transports conjugated steroids (dehydroepiandrosterone sulfate, estradiol- 17β-glucuronide, and estrone-3-sulfate), eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, leukotriene E4), and thyroid hormones (thyroxine, K(m) = 3.0 μM and triiodothyronine, K(m) = 2.7 μM), reflecting hepatic multispecificity. LST-1 is probably the most important transporter in human liver for clearance of bile acids and organic anions because hepatic levels of another organic union transporter, OATP, is very low. This is also the first report of the human molecule that transports thyroid hormones.

Original languageEnglish
Pages (from-to)17159-17163
Number of pages5
JournalJournal of Biological Chemistry
Volume274
Issue number24
DOIs
Publication statusPublished - 1999 Jun 11

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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