Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene

Shintaro Amae, Ken-Ichi Yasumoto, Kazuhisa Takeda, Tetsuo Udono, Kazuhiro Takahashi, Shigeki Shibahara

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The human tyrosinase-related protein 2 (TRP-2) gene promoter contains a cis-regulatory element (positions -447 to -416), termed DOPAchrome tautomerase distal enhancer 1 (DDE1). DDE1 functions as an enhancer in cultured melanoma cells and its core element includes a potential binding site for transcription factors containing a high-mobility-group domain. This core element is bound in vitro by multiple nuclear proteins, which are preferentially expressed in melanoma cells. DDE1 represents a composite enhancer that may be involved in melanocyte-specific transcription of the human TRP-2 gene. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)505-508
Number of pages4
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1492
Issue number2-3
DOIs
Publication statusPublished - 2000 Jul 24

Keywords

  • DOPAchrome tautomerase
  • Gene transcription
  • Melanin
  • Melanocyte
  • Neural crest
  • Tyrosinase-related protein 2

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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