Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene

Shintaro Amae; Ken ichi Yasumoto; Kazuhisa Takeda; Tetsuo Udono; Kazuhiro Takahashi; Shigeki Shibahara

doi:10.1016/S0167-4781(00)00125-1

Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene

Shintaro Amae, Ken ichi Yasumoto, Kazuhisa Takeda, Tetsuo Udono, Kazuhiro Takahashi, Shigeki Shibahara

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The human tyrosinase-related protein 2 (TRP-2) gene promoter contains a cis-regulatory element (positions -447 to -416), termed DOPAchrome tautomerase distal enhancer 1 (DDE1). DDE1 functions as an enhancer in cultured melanoma cells and its core element includes a potential binding site for transcription factors containing a high-mobility-group domain. This core element is bound in vitro by multiple nuclear proteins, which are preferentially expressed in melanoma cells. DDE1 represents a composite enhancer that may be involved in melanocyte-specific transcription of the human TRP-2 gene. Copyright (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	505-508
Number of pages	4
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1492
Issue number	2-3
DOIs	https://doi.org/10.1016/S0167-4781(00)00125-1
Publication status	Published - 2000 Jul 24

Keywords

DOPAchrome tautomerase
Gene transcription
Melanin
Melanocyte
Neural crest
Tyrosinase-related protein 2

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

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10.1016/S0167-4781(00)00125-1

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title = "Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene",

abstract = "The human tyrosinase-related protein 2 (TRP-2) gene promoter contains a cis-regulatory element (positions -447 to -416), termed DOPAchrome tautomerase distal enhancer 1 (DDE1). DDE1 functions as an enhancer in cultured melanoma cells and its core element includes a potential binding site for transcription factors containing a high-mobility-group domain. This core element is bound in vitro by multiple nuclear proteins, which are preferentially expressed in melanoma cells. DDE1 represents a composite enhancer that may be involved in melanocyte-specific transcription of the human TRP-2 gene. Copyright (C) 2000 Elsevier Science B.V.",

keywords = "DOPAchrome tautomerase, Gene transcription, Melanin, Melanocyte, Neural crest, Tyrosinase-related protein 2",

author = "Shintaro Amae and Yasumoto, {Ken ichi} and Kazuhisa Takeda and Tetsuo Udono and Kazuhiro Takahashi and Shigeki Shibahara",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (B), for Scientific Research on Priority Areas, and for Encouragement of Young Scientists (to K.Y.) from the Ministry of Education, Science, Sports, and Culture of Japan. This work was also supported in part by the Nakatomi Foundation and the Kao Foundation for Arts and Sciences.",

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doi = "10.1016/S0167-4781(00)00125-1",

language = "English",

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AU - Amae, Shintaro

AU - Yasumoto, Ken ichi

AU - Takeda, Kazuhisa

AU - Udono, Tetsuo

AU - Takahashi, Kazuhiro

AU - Shibahara, Shigeki

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (B), for Scientific Research on Priority Areas, and for Encouragement of Young Scientists (to K.Y.) from the Ministry of Education, Science, Sports, and Culture of Japan. This work was also supported in part by the Nakatomi Foundation and the Kao Foundation for Arts and Sciences.

PY - 2000/7/24

Y1 - 2000/7/24

N2 - The human tyrosinase-related protein 2 (TRP-2) gene promoter contains a cis-regulatory element (positions -447 to -416), termed DOPAchrome tautomerase distal enhancer 1 (DDE1). DDE1 functions as an enhancer in cultured melanoma cells and its core element includes a potential binding site for transcription factors containing a high-mobility-group domain. This core element is bound in vitro by multiple nuclear proteins, which are preferentially expressed in melanoma cells. DDE1 represents a composite enhancer that may be involved in melanocyte-specific transcription of the human TRP-2 gene. Copyright (C) 2000 Elsevier Science B.V.

AB - The human tyrosinase-related protein 2 (TRP-2) gene promoter contains a cis-regulatory element (positions -447 to -416), termed DOPAchrome tautomerase distal enhancer 1 (DDE1). DDE1 functions as an enhancer in cultured melanoma cells and its core element includes a potential binding site for transcription factors containing a high-mobility-group domain. This core element is bound in vitro by multiple nuclear proteins, which are preferentially expressed in melanoma cells. DDE1 represents a composite enhancer that may be involved in melanocyte-specific transcription of the human TRP-2 gene. Copyright (C) 2000 Elsevier Science B.V.

KW - DOPAchrome tautomerase

KW - Gene transcription

KW - Melanin

KW - Melanocyte

KW - Neural crest

KW - Tyrosinase-related protein 2

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Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene

Abstract

Keywords

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