Abstract
We previously identified two commonly deleted regions on chromosome hands 10q25-q26 in endometrial cancer: an 8-cM region and a 12-cM region. In the present study, we further studied the 8-cM region with 83 endometrial cancer specimens and 14 microsatellite markers and narrowed it down to a 1- cM region between D10S587 and D10S1723. This result was confirmed by two- color fluorescence in situ hybridization analysis. An association between histopathologically lower grade tumor and allelic loss (P = 0.03 by Fisher's exact test) was also observed. We also constructed a yeast artificial chromosome (YAC) contig and found that one YAC clone, which was 790 kb in size, harbored the whole 1-cM region of common allelic loss.
| Original language | English |
|---|---|
| Pages (from-to) | 1630-1633 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 57 |
| Issue number | 9 |
| Publication status | Published - 1997 May 1 |
ASJC Scopus subject areas
- Oncology
- Cancer Research