Identification of a 7-cM region of frequent allelic loss on chromosome band 16p13.3 that is specifically associated with anaplastic thyroid carcinoma

Masao Kadota, Yasuhiro Tamaki, Isao Sakita, Yoshifumi Komoike, Michihiko Miyazaki, Masaru Ooka, Norikazu Masuda, Yoshiyuki Fujiwara, Tadashi Ohnishi, Naohiro Tomita, Mitsugu Sekimoto, Masayuki Ohue, Takayuki Ikeda, Tetsuro Kobayashi, Akira Horii, Morito Monden

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A total of 17 primary thyroid cancer specimens including seven anaplastic cancers, two papillary cancers adjacent to the anaplastic cancers, and eight papillary cancers were analyzed for loss of heterozygosity (LOH) on chromosome arm 16p. All tumors of anaplastic cancer showed LOHs at one or more loci, and a 7-cM region of the smallest deleted region was found on 16p13.3 between D16S423 and D16S406. This LOH was specifically found in the anaplastic cancer and not in the papillary thyroid cancer. Our present results suggest localization of the putative tumor suppressor gene on 16p13.3, which is likely to play an important role in the anaplastic transformation of thyroid cancer.

Original languageEnglish
Pages (from-to)529-533
Number of pages5
JournalOncology reports
Volume7
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • Anaplastic thyroid cancer
  • Anaplastic transformation
  • Loss of heterozygosity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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