Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS

Y. Ikejiri, Etsuro Mori, K. Ishii, K. Nishimoto, M. Yasuda, M. Sasaki

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

We report a 36-year-old man with MELAS in whom a 5-month course of high- dose oral idebenone, a derivative of coenzyme Q10, increased markedly cerebral metabolic ratio of oxygen and oxygen extraction fraction without increased cerebral blood flow with PET. The results indicate that idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS.

Original languageEnglish
Pages (from-to)583-585
Number of pages3
JournalNeurology
Volume47
Issue number2
DOIs
Publication statusPublished - 1996 Jan 1

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS'. Together they form a unique fingerprint.

Cite this