Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

Takahiro Nagatake, Satoshi Fukuyama, Dong Young Kim, Kaoru Goda, Osamu Igarashi, Shintaro Sato, Tomonori Nochi, Hiroshi Sagara, Yoshifumi Yokota, Anton M. Jetten, Tsuneyasu Kaisho, Shizuo Akira, Hitomi Mimuro, Chihiro Sasakawa, Yoshinori Fukui, Kohtaro Fujihashi, Taishin Akiyama, Jun Ichiro Inoue, Josef M. Penninger, Jun KunisawaHiroshi Kiyono

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/differentiation 2, retinoic acid-related orphan receptor γt, lymphotoxin (LT) α1β2-LTβR, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.

Original languageEnglish
Pages (from-to)2351-2364
Number of pages14
JournalJournal of Experimental Medicine
Volume206
Issue number11
DOIs
Publication statusPublished - 2009 Oct 26

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Nagatake, T., Fukuyama, S., Kim, D. Y., Goda, K., Igarashi, O., Sato, S., Nochi, T., Sagara, H., Yokota, Y., Jetten, A. M., Kaisho, T., Akira, S., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J. I., Penninger, J. M., ... Kiyono, H. (2009). Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity. Journal of Experimental Medicine, 206(11), 2351-2364. https://doi.org/10.1084/jem.20091436