TY - CHAP
T1 - IκB-ζ
T2 - An Inducible Regulator of Nuclear Factor-κB
AU - Muta, Tatsushi
N1 - Funding Information:
The author would like to express sincere thanks to Koichiro Takeshige, Soh Yamazaki, and all other collaborators. The author's works were supported in part by grants‐in‐aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan, and grants from Sumitomo Foundation, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, the Naito Foundation, and the Kaibara Foundation.
PY - 2006
Y1 - 2006
N2 - The innate immune system responds to various microbial substances to elicit production of cytokines, chemokines, and costimulatory molecules that regulate activation of the acquired immune system. Although the transcription factor nuclear factor (NF)11The abbreviations used are: ARE, AU-rich element; IL, interleukin; LPS, lipopolysaccharide; NF, nuclear factor; TAK, transforming growth factor-activated kinase; TIR, Toll/IL-1 receptor; TLR, Toll-like receptor; TNF, tumor necrosis factor; TRAF, TNF receptor-associated factor.-κB plays central roles in the induction, it remains to be clarified how appropriate genes are selectively activated with appropriate timing and duration by the multifunctional transcription factor after integration of signals activated by invasion of various pathogens. IκB-ζ is barely detectable in resting cells and is strongly induced upon stimulation of the innate immune system. The induced IκB-ζ associates with the NF-κB subunit in the nucleus and regulates its transcriptional activity both positively and negatively depending on genes. Thus, the innate immune system utilizes NF-κB as a major transcription factor and modulates its activity in a gene-specific manner by the regulatory factor IκB-ζ, which is specifically induced upon stimulation of the innate immune system. This multistep regulation of the transcription would be fundamental in selective expression of genes upon cell activation.
AB - The innate immune system responds to various microbial substances to elicit production of cytokines, chemokines, and costimulatory molecules that regulate activation of the acquired immune system. Although the transcription factor nuclear factor (NF)11The abbreviations used are: ARE, AU-rich element; IL, interleukin; LPS, lipopolysaccharide; NF, nuclear factor; TAK, transforming growth factor-activated kinase; TIR, Toll/IL-1 receptor; TLR, Toll-like receptor; TNF, tumor necrosis factor; TRAF, TNF receptor-associated factor.-κB plays central roles in the induction, it remains to be clarified how appropriate genes are selectively activated with appropriate timing and duration by the multifunctional transcription factor after integration of signals activated by invasion of various pathogens. IκB-ζ is barely detectable in resting cells and is strongly induced upon stimulation of the innate immune system. The induced IκB-ζ associates with the NF-κB subunit in the nucleus and regulates its transcriptional activity both positively and negatively depending on genes. Thus, the innate immune system utilizes NF-κB as a major transcription factor and modulates its activity in a gene-specific manner by the regulatory factor IκB-ζ, which is specifically induced upon stimulation of the innate immune system. This multistep regulation of the transcription would be fundamental in selective expression of genes upon cell activation.
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U2 - 10.1016/S0083-6729(06)74012-2
DO - 10.1016/S0083-6729(06)74012-2
M3 - Chapter
C2 - 17027520
AN - SCOPUS:33947715520
SN - 0127098747
SN - 9780127098746
T3 - Vitamins and Hormones
SP - 301
EP - 316
BT - Interleukins
A2 - Litwack, Gerald
ER -