HzAnalyzer: Detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets

Todd A. Johnson, Yoshihito Niimura, Hiroshi Tanaka, Yusuke Nakamura, Tatsuhiko Tsunoda

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The analysis of contiguous homozygosity (runs of homozygous loci) in human genotyping datasets is critical in the search for causal disease variants in monogenic disorders, studies of population history and the identification of targets of natural selection. Here, we report methods for extracting homozygous segments from high-density genotyping datasets, quantifying their local genomic structure, identifying outstanding regions within the genome and visualizing results for comparative analysis between population samples.

Original languageEnglish
Article numberR21
JournalGenome biology
Volume12
Issue number3
DOIs
Publication statusPublished - 2011 Mar 11

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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