TY - JOUR
T1 - Hypotensive effect of captopril in relation to plasma renin activity in anesthetized rats.
AU - Satoh, Susumu
AU - Suzuki, Mizue
AU - Satoh, Hiroko
PY - 1980/1/1
Y1 - 1980/1/1
N2 - The effect of captopril (D-3-mercapto-2-methylpropanoyl-L-proline), a converting enzyme inhibitor, on the systemic blood pressure in pentobarbital anesthetized rats was investigated. Experiments were performed in four groups of rats: untreated, Na-restricted, furosemide treated and bilaterally nephrectomized, respectively. Intravenous injection of 1 mg/kg of captopril caused a significant hypotensive effect in the three groups of rats but not in the nephrectomized group. Individual values for the hypotensive effect produced by captopril and plasma renin activity obtained just before injection of captopril showed a highly significant correlation.
AB - The effect of captopril (D-3-mercapto-2-methylpropanoyl-L-proline), a converting enzyme inhibitor, on the systemic blood pressure in pentobarbital anesthetized rats was investigated. Experiments were performed in four groups of rats: untreated, Na-restricted, furosemide treated and bilaterally nephrectomized, respectively. Intravenous injection of 1 mg/kg of captopril caused a significant hypotensive effect in the three groups of rats but not in the nephrectomized group. Individual values for the hypotensive effect produced by captopril and plasma renin activity obtained just before injection of captopril showed a highly significant correlation.
KW - anesthetized rat
KW - captopril
KW - converting enzyme inhibitor
KW - hypotensive effect
KW - plasma renin activity
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U2 - 10.1248/bpb1978.3.258
DO - 10.1248/bpb1978.3.258
M3 - Article
C2 - 6997455
AN - SCOPUS:0019310912
VL - 3
SP - 258
EP - 260
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 5
ER -