Hypotensive effect of captopril in relation to plasma renin activity in anesthetized rats.

Susumu Satoh, Mizue Suzuki, Hiroko Satoh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of captopril (D-3-mercapto-2-methylpropanoyl-L-proline), a converting enzyme inhibitor, on the systemic blood pressure in pentobarbital anesthetized rats was investigated. Experiments were performed in four groups of rats: untreated, Na-restricted, furosemide treated and bilaterally nephrectomized, respectively. Intravenous injection of 1 mg/kg of captopril caused a significant hypotensive effect in the three groups of rats but not in the nephrectomized group. Individual values for the hypotensive effect produced by captopril and plasma renin activity obtained just before injection of captopril showed a highly significant correlation.

Original languageEnglish
Pages (from-to)258-260
Number of pages3
Journaljournal of pharmacobio-dynamics
Volume3
Issue number5
DOIs
Publication statusPublished - 1980 Jan 1

Keywords

  • anesthetized rat
  • captopril
  • converting enzyme inhibitor
  • hypotensive effect
  • plasma renin activity

ASJC Scopus subject areas

  • Pharmacology

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