Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Michihiro Satoh, Taku Obara, Urara Ikeda, Yuka Kobayashi, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalClinical and Experimental Hypertension
Volume34
Issue number4
DOIs
Publication statusPublished - 2012 Jul

Keywords

  • antihypertensive drug
  • bisoprolol
  • home blood pressure
  • home heart rate
  • lowering effect
  • stabilizing time
  • β-blocker

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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