Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Michihiro Satoh; Taku Obara; Urara Ikeda; Yuka Kobayashi; Hirohito Metoki; Kei Asayama; Masahiro Kikuya; Takayoshi Ohkubo; Yutaka Imai

doi:10.3109/10641963.2012.681085

Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Michihiro Satoh, Taku Obara, Urara Ikeda, Yuka Kobayashi, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.

Original language	English
Pages (from-to)	284-289
Number of pages	6
Journal	Clinical and Experimental Hypertension
Volume	34
Issue number	4
DOIs	https://doi.org/10.3109/10641963.2012.681085
Publication status	Published - 2012 Jul

Keywords

antihypertensive drug
bisoprolol
home blood pressure
home heart rate
lowering effect
stabilizing time
β-blocker

ASJC Scopus subject areas

Internal Medicine
Physiology

Access to Document

10.3109/10641963.2012.681085

Cite this

Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home. / Satoh, Michihiro; Obara, Taku; Ikeda, Urara; Kobayashi, Yuka; Metoki, Hirohito; Asayama, Kei; Kikuya, Masahiro; Ohkubo, Takayoshi; Imai, Yutaka.

In: Clinical and Experimental Hypertension, Vol. 34, No. 4, 07.2012, p. 284-289.

Research output: Contribution to journal › Article › peer-review

@article{2e7cca736d3345b898f0e0157a624378,

title = "Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home",

abstract = "We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.",

keywords = "antihypertensive drug, bisoprolol, home blood pressure, home heart rate, lowering effect, stabilizing time, β-blocker",

author = "Michihiro Satoh and Taku Obara and Urara Ikeda and Yuka Kobayashi and Hirohito Metoki and Kei Asayama and Masahiro Kikuya and Takayoshi Ohkubo and Yutaka Imai",

note = "Funding Information: This study was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology.",

year = "2012",

month = jul,

doi = "10.3109/10641963.2012.681085",

language = "English",

volume = "34",

pages = "284--289",

journal = "Clinical and Experimental Hypertension",

issn = "1064-1963",

publisher = "Informa Healthcare",

number = "4",

}

TY - JOUR

T1 - Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

AU - Satoh, Michihiro

AU - Obara, Taku

AU - Ikeda, Urara

AU - Kobayashi, Yuka

AU - Metoki, Hirohito

AU - Asayama, Kei

AU - Kikuya, Masahiro

AU - Ohkubo, Takayoshi

AU - Imai, Yutaka

N1 - Funding Information: This study was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology.

PY - 2012/7

Y1 - 2012/7

N2 - We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.

AB - We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.

KW - antihypertensive drug

KW - bisoprolol

KW - home blood pressure

KW - home heart rate

KW - lowering effect

KW - stabilizing time

KW - β-blocker

UR - http://www.scopus.com/inward/record.url?scp=84862235725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862235725&partnerID=8YFLogxK

U2 - 10.3109/10641963.2012.681085

DO - 10.3109/10641963.2012.681085

M3 - Article

C2 - 22571411

AN - SCOPUS:84862235725

VL - 34

SP - 284

EP - 289

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

SN - 1064-1963

IS - 4

ER -

Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this