Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Michihiro Satoh; Taku Obara; Urara Ikeda; Yuka Kobayashi; Hirohito Metoki; Kei Asayama; Masahiro Kikuya; Takayoshi Ohkubo; Yutaka Imai

doi:10.3109/10641963.2012.681085

Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home

Michihiro Satoh, Taku Obara, Urara Ikeda, Yuka Kobayashi, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.

Original language	English
Pages (from-to)	284-289
Number of pages	6
Journal	Clinical and Experimental Hypertension
Volume	34
Issue number	4
DOIs	https://doi.org/10.3109/10641963.2012.681085
Publication status	Published - 2012 Jul

Keywords

antihypertensive drug
bisoprolol
home blood pressure
home heart rate
lowering effect
stabilizing time
β-blocker

ASJC Scopus subject areas

Internal Medicine
Physiology

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Hypotensive and heart rate-lowering effects of low-dose bisoprolol determined based on self-measured blood pressure at home. / Satoh, Michihiro; Obara, Taku; Ikeda, Urara; Kobayashi, Yuka; Metoki, Hirohito; Asayama, Kei; Kikuya, Masahiro; Ohkubo, Takayoshi; Imai, Yutaka.

In: Clinical and Experimental Hypertension, Vol. 34, No. 4, 07.2012, p. 284-289.

Research output: Contribution to journal › Article › peer-review

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abstract = "We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.",

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AU - Ikeda, Urara

AU - Kobayashi, Yuka

AU - Metoki, Hirohito

AU - Asayama, Kei

AU - Kikuya, Masahiro

AU - Ohkubo, Takayoshi

AU - Imai, Yutaka

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