Hypotensive and bradycardic effects of centrally administered vasopressin in stroke-prone spontaneously hypertensive rats

Yutaka Imai, Keishi Abe, Shuichi Sasakj, Naoyoshi Minami, Toshima Nobunaga, Hiroshi Sekino, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The cardiovascular effects of centrally administered arginine vasopressin were studied in strokeprone spontaneously hypertensive rats and Wistar-Kyoto rats. Arginine vasopressin was infused intracerebroventricularly into conscious rats at a rate of 2 pg/kg/min (4.6,1/hr) for 21 hours, and blood pressure and heart rate were monitored. Arginine vasopressin caused transient hypertension and tachycardia in Wistar-Kyoto rats, whereas it induced delayed hypotension and bradycardia in stroke-prone spontaneously hypertensive rats. The effects on the latter lasted for 24 to 72 hours after cessation of the infusion. Intravenous administration of arginine vasopressin at a rate of 2 pg/kg/min did not cause any change in blood pressure and heart rate in these rats. These results suggest that arginine vasopressin acts centrally to depress cardiovascular activities, at least in stroke-prone spontaneously hypertensive rats.

Original languageEnglish
Pages (from-to)346-349
Number of pages4
JournalHypertension
Volume10
Issue number3
DOIs
Publication statusPublished - 1987 Sep

Keywords

  • Blood pressure
  • Heart rate
  • Intracerebroventricular administration
  • Stroke-prone spontaneously hypertensive rats
  • Wistar-kyoto rats

ASJC Scopus subject areas

  • Internal Medicine

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